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Gene : AG A. thaliana

Gene ID  ? AT4G18960
Brief Description  K-box region and MADS-box transcription factor family protein  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? AGAMOUS (AG); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: stamen development, maintenance of floral organ identity, leaf development, carpel development; LOCATED IN: nucleus; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT3G58780.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Floral homeotic gene encoding a MADS domain transcription factor. Specifies floral meristem and carpel and stamen identity. Binds CArG box sequences. It is the only C function gene. It interacts genetically with the other homeotic genes to specify the floral organs.  Source: TAIR, Jun 30, 2015.

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19 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
floral phenotype of bellringer mutants is caused by derepression of AG, suggesting that BLR functions as a transcription repressor 15155890
AG activates biosynthesis of gibberellin, which has been proposed to promote the shift from meristem identity to differentiation 15634696
The data provides genetic evidence for the role of AP1 in these interactions by showing that the floral phenotype in the ap1 agl24 svp triple mutant is significantly enhanced. 16679456
AG and miR172 have distinct functions in flower development and that they largely act independently in the negative regulation of AP2. 17573799
The Arabidopsis homologs of trithorax (ATX1) and enhancer of zeste (CLF) interact to control the expression of the flower homeotic gene AGAMOUS. 17881378
These results indicate that stamen identity and differentiation control by AG is achieved by the regulation of different transcriptional cascades in different floral stages. 17981996
Transgenic Arabidopsis plants harboring two tissue-specific promoters, fAGIP and rAGIP in forward and reverse orientations, fAGIP::GUS or rAGIP::GUS displayed similar GUS expression specifically in carpel and stamen tissues and their primordial cells. 18256838
PERIANTHIA (PAN) plays a role in regulating stem cell fate by directly controlling AG expression and suggest that this activity is spatially restricted to the centermost region of the AG expression domain. 19395638
Upon enhanced central AG expression, the C-domain laterally expands necessitating tuning of the expression level of C-function genes in the wild type. 19554348
GIANT KILLER (AT2G35270) acts as a molecular node downstream of AGAMOUS, regulating patterning and differentiation of reproductive organs through chromatin organization 19956801
A model in which the decision whether stamens or petals develop is based on the balance between AP2 and AG activities, rather than the two being mutually exclusive. 20876650
Interaction between the PINOID/ABRUPTUS gene with the AGAMOUS gene: the negative regulator of stem cells in the meristem of Arabidopsis thaliana flower 21542343
AGAMOUS directly represses WUS expression by binding to the WUS locus and recruiting, directly or indirectly, PcG that methylates histone H3 Lys-27 at WUS. 22028461
in the delicately balanced regulatory network, NSN1 acts to repress AG and plays an additive role with AP2 in floral organ specification. 22357616
Data indicate that C function regulator AGAMOUS and the B function regulators APETALA3 and PISTILLATA control many developmental processes in conjunction, as well as independent activities. 23821642
In the floral meristem, the binding of AG to WUS is reduced in top1a-2, which results in reduced H3K27me3 levels at WUS and prolonged WUS expression, and consequently loss of floral determinacy. 25070639
ARF3 integrates the functions of AGAMOUS and APETALA2 in floral meristem determinacy. 25187180
The ULT1 and LFY pathways act separately in regulating identity and determinacy at the floral meristem. In particular, they independently induce AG expression in the centre of the flower to terminate meristem activity. 25288633
FLK and PEP physically interact with proteins involved in AG pre-mRNA processing to secure correct AG function in the floral meristem and flower 25658099


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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT4G18960 0.5kb upstream 0.5kb upstream 6184   true Chr4: 10382356-10388539
AT4G18960 0.5kb upstream 0.5kb upstream 500   false Chr4: 10382356-10382855
AT4G18960 0.5kb downstream 0.5kb downstream 6184   true Chr4: 10382856-10389039
AT4G18960 0.5kb downstream 0.5kb downstream 500   false Chr4: 10388540-10389039
AT4G18960 1.0kb upstream 1.0kb upstream 6684   true Chr4: 10381856-10388539
AT4G18960 1.0kb upstream 1.0kb upstream 1000   false Chr4: 10381856-10382855
AT4G18960 1.0kb downstream 1.0kb downstream 6684   true Chr4: 10382856-10389539
AT4G18960 1.0kb downstream 1.0kb downstream 1000   false Chr4: 10388540-10389539
AT4G18960 3.0kb upstream 3.0kb upstream 8684   true Chr4: 10379856-10388539
AT4G18960 3.0kb upstream 3.0kb upstream 3000   false Chr4: 10379856-10382855
AT4G18960 3.0kb downstream 3.0kb downstream 8684   true Chr4: 10382856-10391539
AT4G18960 3.0kb downstream 3.0kb downstream 3000   false Chr4: 10388540-10391539


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11 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from TAIR GO annotations assigned by TAIR 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139