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Gene : BRX A. thaliana

Gene ID  ? AT1G31880
Brief Description  DZC (Disease resistance/zinc finger/chromosome condensation-like region) domain containing protein  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? BREVIS RADIX (BRX); CONTAINS InterPro DOMAIN/s: Disease resistance/zinc finger/chromosome condensation-like region (InterPro:IPR013591); BEST Arabidopsis thaliana protein match is: BREVIS RADIX-like 1 (TAIR:AT2G35600.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Belongs to five-member BRX gene family. Arabidopsis BRX genes share high levels of similarity among each others, with several conserved domains. The most distinct is BRX domain - highly conserved in all BRX genes among distantly related species. This protein-protein interaction domain is required and sufficient for BRX activity. BRX encodes a key regulator of cell proliferation and elongation in the root, which has been implicated in the brassinosteroid (BR) pathway as well as regulation of auxin-responsive gene expression. Also involved in cytokinin-mediated inhibition of lateral root initiation. A loss-of-function allele, named brx-2 in Rodrigues et al. (2009) Plant Physiol. but changed to brx-3 to resolve nomenclature conflict (Li et al. Planta 2009:229(3):593-603), shows enhanced response to ABA-mediated inhibition of root growth.  Source: TAIR, Jun 30, 2015.
  • synonyms:
  • NLM9

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9 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
The brx phenotype results from a root-specific deficiency of brassinosteroid and is due to reduced, BRX-dependent expression of a rate-limiting enzyme in brassinosteroid biosynthesis [BRX] 17006513
A brx loss-of-function allele, which was found in a natural accession, results in a highly branched but poorly elongated root system. 18627499
BRX is associated with cytokinin-mediated inhibition of lateral root initiation. 19037657
A loss-of-function allele of BREVIS RADIX (BRX) in the Columbia background, named brx-2, which shows enhanced response to ABA-mediated inhibition of root growth, was identified. 19201913
BRX might provide a contextual readout to synchronize cellular growth with the auxin concentration gradient across the root tip. 19465596
AtBRX(Lc-0) allele seems to contribute to natural variation in root growth vigor and provides a rare example of an experimentally confirmed, hyperactive allelic variant. 20404146
These results demonstrate a ubiquitous, although quantitatively variable role of BRX in modulating the growth rate in both the root and shoot. 20649916
Data suggest a model in which the regulatory interactions favor BRX expression in the early proximal meristem and SHY2 prevails because of supplementary cytokinin induction in the later distal meristem. 21149702
a novel brx allele from another acidic sampling site demonstrates the existence of independently maintained brx loss-of-function alleles in nature and supports the notion that they are advantageous in acidic soil pH conditions. 23041192


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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT1G31880 0.5kb upstream 0.5kb upstream 5243   true Chr1: 11444990-11450232
AT1G31880 0.5kb upstream 0.5kb upstream 500   false Chr1: 11444990-11445489
AT1G31880 0.5kb downstream 0.5kb downstream 5243   true Chr1: 11445490-11450732
AT1G31880 0.5kb downstream 0.5kb downstream 500   false Chr1: 11450233-11450732
AT1G31880 1.0kb upstream 1.0kb upstream 5743   true Chr1: 11444490-11450232
AT1G31880 1.0kb upstream 1.0kb upstream 1000   false Chr1: 11444490-11445489
AT1G31880 1.0kb downstream 1.0kb downstream 5743   true Chr1: 11445490-11451232
AT1G31880 1.0kb downstream 1.0kb downstream 1000   false Chr1: 11450233-11451232
AT1G31880 3.0kb upstream 3.0kb upstream 7743   true Chr1: 11442490-11450232
AT1G31880 3.0kb upstream 3.0kb upstream 3000   false Chr1: 11442490-11445489
AT1G31880 3.0kb downstream 3.0kb downstream 7743   true Chr1: 11445490-11453232
AT1G31880 3.0kb downstream 3.0kb downstream 3000   false Chr1: 11450233-11453232


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0 Pathways

Data Source: KEGG

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11 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from TAIR GO annotations assigned by TAIR 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139