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Gene : MCM2 A. thaliana

Gene ID  ? AT1G44900
Brief Description  minichromosome maintenance (MCM2/3/5) family protein  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? MINICHROMOSOME MAINTENANCE 2 (MCM2); FUNCTIONS IN: DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: in 7 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 2 (InterPro:IPR008045), MCM protein 2, N-terminal (InterPro:IPR021092); BEST Arabidopsis thaliana protein match is: Minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT2G16440.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes MCM2 (MINICHROMOSOME MAINTENANCE 2), a protein essential to embryo development. Overexpression results in altered root meristem function.  Source: TAIR, Jun 30, 2015.
Name  ? MINICHROMOSOME MAINTENANCE 2
  • synonyms:
  • ATMCM2

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2 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
Disruption of AtMCM2 is lethal at a very early stage of embryogenesis, whereas its over-expression results in reduced growth and inhibition of endoreduplication. [MCM2] [Minichromosome maintenance protein 2] 19650778
Authors demonstrated an interaction between mungbean yellow mosaic India virus-Rep and the host factor Arabidopsis thaliana MCM2. 23242774

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT1G44900 0.5kb upstream 0.5kb upstream 5040   true Chr1: 16969714-16974753
AT1G44900 0.5kb upstream 0.5kb upstream 500   false Chr1: 16969714-16970213
AT1G44900 0.5kb downstream 0.5kb downstream 5040   true Chr1: 16970214-16975253
AT1G44900 0.5kb downstream 0.5kb downstream 500   false Chr1: 16974754-16975253
AT1G44900 1.0kb upstream 1.0kb upstream 5540   true Chr1: 16969214-16974753
AT1G44900 1.0kb upstream 1.0kb upstream 1000   false Chr1: 16969214-16970213
AT1G44900 1.0kb downstream 1.0kb downstream 5540   true Chr1: 16970214-16975753
AT1G44900 1.0kb downstream 1.0kb downstream 1000   false Chr1: 16974754-16975753
AT1G44900 3.0kb upstream 3.0kb upstream 7540   true Chr1: 16967214-16974753
AT1G44900 3.0kb upstream 3.0kb upstream 3000   false Chr1: 16967214-16970213
AT1G44900 3.0kb downstream 3.0kb downstream 7540   true Chr1: 16970214-16977753
AT1G44900 3.0kb downstream 3.0kb downstream 3000   false Chr1: 16974754-16977753

Proteins

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Function

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1 Pathways

Data Source: KEGG

Identifier Name
03030 DNA replication

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Expression

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12 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from UniProt GO annotations assigned by UniProt 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139