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Gene : AP1 A. thaliana

Gene ID  ? AT1G69120
Brief Description  K-box region and MADS-box transcription factor family protein  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? APETALA1 (AP1); CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT1G26310.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Floral homeotic gene encoding a MADS domain protein homologous to SRF transcription factors. Specifies floral meristem and sepal identity. Required for the transcriptional activation of AGAMOUS. Interacts with LEAFY.Binds to promoter and regulates the expression of flowering time genes SVP, SOC1 and AGL24.  Source: TAIR, Jun 30, 2015.
Name  ? APETALA1
  • synonyms:
  • AGAMOUS-like 7,
  • AtAP1,
  • AGL7

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19 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
The floral homeotic PISTILLATA (PI) protein and its interacting partner APETALA3 directly act, in combination with other factors, to restrict the expression of AP1 during early stages of floral development. 16640596
The data provides genetic evidence for the role of AP1 in these interactions by showing that the floral phenotype in the ap1 agl24 svp triple mutant is significantly enhanced. 16679456
The unique and redundant functions of the APETALA1 and CAULIFLOWER genes have been mapped to the four protein domains that characterize type-II MADS-domain proteins. 16893974
once AP1 is activated during the floral transition, it acts partly as a master repressor in floral meristems by directly suppressing the expression of flowering time genes SVP, AGL24 and SOC1, preventing continuation of the shoot developmental program 17428825
'Activating' H3K4me3 and 'silencing' H3K27me3 modifications co-exist at 5'-end nucleosomes of transcriptionally active FLC-gene, while highly transcribed AP1 displays neither of the two marks. 18638531
AP1, AGL24 and SVP redundantly control floral meristem identity. 18694458
Angiostatin K1-3 induced E-selectin expression via AP1 and Ets-1 binding to the proximal E-selectin promoter (-356/+1), which was positively mediated by JNK activation. 18761727
AGL24, AP1 and SVP directly and redundantly regulate class B, C and E floral homeotic genes. 19656343
Data show that LEAFY, FRUITFULL, and APETALA1 are directly activated by the microRNA-targeted transcription factor SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 3 (SPL3) to control the timing of flower formation. 19686687
results suggest distinct functions of AP1 during the initiation of flower development 20360106
Interaction between the ABRUPTUS/PINOID and APETALA1 genes regulating the inflorescence development in Arabidopsis thaliana 20391782
Data show that BOP1/2 function distinctly from LFY to upregulate AP1 in floral primordia and that all three activities converge to down-regulate flowering-time regulators including AGAMOUS-LIKE24 in stage 2 floral meristems. 20626659
LEAFY binding site is essential for proper photoperiodic activation of APETALA1 21623976
Data show that the direct LEAFY target LATE MERISTEM IDENTITY2 (LMI2) has a role in the meristem identity transition, and acts together with LEAFY to activate APETALA1. 21750030
Different action of the APETALA1 gene on the development of reproductive organs in flowers of the abruptus mutant of Arabidopsis thaliana 21950056
Co-expression analysis identifies CRC and AP1 the regulator of Arabidopsis fatty acid biosynthesis. 22676405
Approximately 90% of the binding sites of two well-characterized MADS domain transcription factors, APETALA1 and SEPALLATA3, were covered by the DNase I hypersensitive (DH) sites. 22773751
suppression of cytokinin biosynthesis and activation of cytokinin degradation mediates AP1 function in establishing determinate floral meristems 24753595
Data suggest that helix-turn-helix transcription factor LEAFY (LFY) and the MADS box transcription factor APETALA1 (AP1)together orchestrate the switch to flower formation and morphogenesis by altering transcriptional programs. 26096587

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT1G69120 0.5kb upstream 0.5kb upstream 4556   true Chr1: 25982294-25986849
AT1G69120 0.5kb upstream 0.5kb upstream 500   false Chr1: 25986350-25986849
AT1G69120 0.5kb downstream 0.5kb downstream 4556   true Chr1: 25981794-25986349
AT1G69120 0.5kb downstream 0.5kb downstream 500   false Chr1: 25981794-25982293
AT1G69120 1.0kb upstream 1.0kb upstream 5056   true Chr1: 25982294-25987349
AT1G69120 1.0kb upstream 1.0kb upstream 1000   false Chr1: 25986350-25987349
AT1G69120 1.0kb downstream 1.0kb downstream 5056   true Chr1: 25981294-25986349
AT1G69120 1.0kb downstream 1.0kb downstream 1000   false Chr1: 25981294-25982293
AT1G69120 3.0kb upstream 3.0kb upstream 7056   true Chr1: 25982294-25989349
AT1G69120 3.0kb upstream 3.0kb upstream 3000   false Chr1: 25986350-25989349
AT1G69120 3.0kb downstream 3.0kb downstream 7056   true Chr1: 25979294-25986349
AT1G69120 3.0kb downstream 3.0kb downstream 3000   false Chr1: 25979294-25982293

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11 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from TIGR GO annotations assigned by TIGR Arabidopsis annotation effort 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139