help  | faq  | software  | ARAPORT

Gene : SKP1 A. thaliana

Gene ID  ? AT1G75950
Brief Description  S phase kinase-associated protein 1  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? S phase kinase-associated protein 1 (SKP1); FUNCTIONS IN: ubiquitin-protein ligase activity, protein binding; INVOLVED IN: negative regulation of DNA recombination, response to cadmium ion, mitosis, male meiosis, ubiquitin-dependent protein catabolic process; LOCATED IN: in 7 components; EXPRESSED IN: 35 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: E3 ubiquitin ligase, SCF complex, Skp subunit (InterPro:IPR016897), SKP1 component, dimerisation (InterPro:IPR016072), SKP1 component (InterPro:IPR001232), BTB/POZ fold (InterPro:IPR011333), SKP1 component, POZ (InterPro:IPR016073); BEST Arabidopsis thaliana protein match is: E3 ubiquitin ligase SCF complex subunit SKP1/ASK1 family protein (TAIR:AT5G42190.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? SKP1 is core component of the SCF family of E3 ubiquitin ligases and serves to tether the rest of the complex to an F-box protein, which provides specificity in binding to ubiquitin ligase substrate proteins. Predominately expressed from leptotene to pachytene. Negatively regulates recombination. Interacts with P0, a silencing suppressor protein encoded by poleroviruses by means of a conserved minimal F-box motif.  Source: TAIR, Jun 30, 2015.
Name  ? S phase kinase-associated protein 1
  • synonyms:
  • ASK1,
  • SKP1A,
  • ATSKP1,
  • UIP1,
  • ARABIDOPSIS SKP1 HOMOLOGUE 1,
  • UFO INTERACTING PROTEIN 1

Locus History Displayer

Publication Counts Displayer

11 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
ASK1 is predominately expressed from leptotene to pachytene, and negatively regulates recombination in Arabidopsis. 16283376
Through the ASK1-mediated proteolysis pathway, ASK1 proteins showed pleiotropic functions including photomorphogenesis, circadian oscillation, post-translation process, stress-responses and cell expansion or elongation. 16699544
Through the ASK1-mediated proteolysis pathway, ASK1 proteins showed pleiotropic functions including photomorphogenesis, circadian oscillation, post-translation process, stress-responses and cell expansion or elongation. 16699544
ASK1 is required for normal SYN1 distribution during meiotic prophase I and suggest that ask1 associated defects may be primarily related to SYN1 mislocalization. 16897472
ASK1 is required for normal SYN1 distribution during meiotic prophase I and suggest that ask1 associated defects may be primarily related to SYN1 mislocalization. 16897472
These results raise the interesting possibility that ASK1 controls chromatin structure by targeting of either an early regulator of meiotic progression or possibly matrix attachment proteins for destruction. 16940350
These results raise the interesting possibility that ASK1 controls chromatin structure by targeting of either an early regulator of meiotic progression or possibly matrix attachment proteins for destruction. 16940350
study represents a thorough investigation showing that retroposition can play an important role in the evolution of a plant gene family whose members do not encode mobile elements 17470057
ASK1 or ASK2 overexpression could rescue or partially rescue the Abscisic acid (ABA)insensitivity of abi5-1 mutants, respectively. 22074111
ASK1 and ASK2, are required for Agrobacterium-mediated plant transformation. 22486382
ABA induced the phosphorylation of three basic helix-loop-helix (bHLH) transcription factors, called AKSs (ABA-responsive kinase substrates; AKS1, AKS2, and AKS3), in Arabidopsis guard cells 23779086

Genomics

Sequence Feature Displayer

Gene Structure Displayer

J Browse Displayer

Overlapping Features Displayer

12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT1G75950 0.5kb upstream 0.5kb upstream 1878   true Chr1: 28516019-28517896
AT1G75950 0.5kb upstream 0.5kb upstream 500   false Chr1: 28516019-28516518
AT1G75950 0.5kb downstream 0.5kb downstream 1878   true Chr1: 28516519-28518396
AT1G75950 0.5kb downstream 0.5kb downstream 500   false Chr1: 28517897-28518396
AT1G75950 1.0kb upstream 1.0kb upstream 2378   true Chr1: 28515519-28517896
AT1G75950 1.0kb upstream 1.0kb upstream 1000   false Chr1: 28515519-28516518
AT1G75950 1.0kb downstream 1.0kb downstream 2378   true Chr1: 28516519-28518896
AT1G75950 1.0kb downstream 1.0kb downstream 1000   false Chr1: 28517897-28518896
AT1G75950 3.0kb upstream 3.0kb upstream 4378   true Chr1: 28513519-28517896
AT1G75950 3.0kb upstream 3.0kb upstream 3000   false Chr1: 28513519-28516518
AT1G75950 3.0kb downstream 3.0kb downstream 4378   true Chr1: 28516519-28520896
AT1G75950 3.0kb downstream 3.0kb downstream 3000   false Chr1: 28517897-28520896

Proteins

Protein Displayer


Function

Gene Ontology Displayer

2 Pathways

Data Source: KEGG

Identifier Name
04141 Protein processing in endoplasmic reticulum
04120 Ubiquitin mediated proteolysis

Gene --> Ontology term

Gene --> Pathways


Expression

Plant Ontology Displayer

Bar Efp Browser Displayer

Array Expression

RNA-seq Expression

Co-expression

Save / Export

 

 

 

 



Interactions

Cytoscape Network Displayer


Homology

Homologue Displayer

Phytomine Ortholog Displayer


Stocks

Alelle Table Displayer

Stock Gene Table Displayer


 

Other

12 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from TIGR GO annotations assigned by TIGR Arabidopsis annotation effort 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139