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Gene : AtPOT1a A. thaliana

Gene ID  ? AT2G05210
Brief Description  Nucleic acid-binding, OB-fold-like protein  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? Protection of Telomeres 1a (AtPOT1a); CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Telomere end binding protein (InterPro:IPR011564); BEST Arabidopsis thaliana protein match is: Nucleic acid-binding, OB-fold-like protein (TAIR:AT5G06310.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes AtPOT1a, an accessory factor for telomerase required for positive telomere length regulation. Note on nomenclature: different names have been given to Arabidopsis POT-like genes (Kuchar and Fajkus, 2004; Shakirov et al, 2005; Tani and Murata, 2005). According to a unifying nomenclature (Surovtseva et al, 2007), At2g05210 (previously named AtPOT1) is designated AtPOT1a, while At5g06310 (previously named AtPOT2) is designated AtPOT1b.  Source: TAIR, Jun 30, 2015.
Name  ? Protection of Telomeres 1a
  • synonyms:
  • ATPOT1

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4 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
AtPot1 (protection of telomeres 1) and AtPot2 are ubiquitously expressed at low levels in Arabidopsis. AtPot1 is essential for telomere length maintenance. [Atpot1] 16107718
Single-strand telomeric DNA binding activity present in A. thaliana nuclear extracts is not dependent on POT1a or POT1b proteins. 19228335
POT1a promotes an extendable telomere state via contacts with the telomerase RNP as well as STN1 and CTC1, while TEN1 opposes these functions. 25329641
Our results reveal a molecular mechanism for the role of these positively selected sites in AtPOT1a. 25697340

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT2G05210 0.5kb upstream 0.5kb upstream 4331   true Chr2: 1890184-1894514
AT2G05210 0.5kb upstream 0.5kb upstream 500   false Chr2: 1890184-1890683
AT2G05210 0.5kb downstream 0.5kb downstream 4331   true Chr2: 1890684-1895014
AT2G05210 0.5kb downstream 0.5kb downstream 500   false Chr2: 1894515-1895014
AT2G05210 1.0kb upstream 1.0kb upstream 4831   true Chr2: 1889684-1894514
AT2G05210 1.0kb upstream 1.0kb upstream 1000   false Chr2: 1889684-1890683
AT2G05210 1.0kb downstream 1.0kb downstream 4831   true Chr2: 1890684-1895514
AT2G05210 1.0kb downstream 1.0kb downstream 1000   false Chr2: 1894515-1895514
AT2G05210 3.0kb upstream 3.0kb upstream 6831   true Chr2: 1887684-1894514
AT2G05210 3.0kb upstream 3.0kb upstream 3000   false Chr2: 1887684-1890683
AT2G05210 3.0kb downstream 3.0kb downstream 6831   true Chr2: 1890684-1897514
AT2G05210 3.0kb downstream 3.0kb downstream 3000   false Chr2: 1894515-1897514

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0 Pathways

Data Source: KEGG

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11 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from GOC GO annotations assigned by the GO Consortium 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139