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Gene : ACO3 A. thaliana

Gene ID  ? AT2G05710
Brief Description  aconitase 3  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? aconitase 3 (ACO3); FUNCTIONS IN: aconitate hydratase activity, copper ion binding, ATP binding; INVOLVED IN: in 6 processes; LOCATED IN: cytosol, mitochondrion, cell wall, plasma membrane, chloroplast; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha (InterPro:IPR001030), Aconitase family, 4Fe-4S cluster binding site (InterPro:IPR018136), Aconitase A/isopropylmalate dehydratase small subunit, swivel (InterPro:IPR000573), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 (InterPro:IPR015932), Aconitase/Iron regulatory protein 2/2-methylisocitrate dehydratase (InterPro:IPR015934), Aconitase-like core (InterPro:IPR015937), Aconitase/3-isopropylmalate dehydratase, swivel (InterPro:IPR015928), Aconitase/iron regulatory protein 2 (InterPro:IPR006249), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 (InterPro:IPR015931); BEST Arabidopsis thaliana protein match is: aconitase 1 (TAIR:AT4G35830.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes an aconitase that can catalyze the conversion of citrate to isocitrate through a cis-aconitate intermediate, indicating that it may participate in the TCA cycle and other primary metabolic pathways. The protein is believed to accumulate in the mitochondria and the cytosol. It affects CSD2 (At2g28190 - a superoxide dismutase) transcript levels and may play a role in the response to oxidative stress. One member of the family (ACO1 - At35830) was shown to specifically bind to the 5' UTR of CSD2 in vitro. ACO3 is tyrosine-phosphorylated and its phosphorylation state is modulated in response to ABA in Arabidopsis thaliana seeds.  Source: TAIR, Jun 30, 2015.
Name  ? aconitase 3

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2 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
The identification of ACO1, ACO2, and ACO3 in A. thaliana is reported, and it was demonstrated that, in plants, the cytosolic ACOs are not converted into iron regulatory proteins. 17437406
PP2A-B'gamma physically interacts with the cytoplasmic form of aconitase and PP2A-B'gamma impacts reactive oxygen species homeostasis by controlling the abundance of specific alternative oxidase isoforms, AOX1A and AOX1D, in leaf mitochondria. 25307043

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT2G05710 0.5kb upstream 0.5kb upstream 5850   true Chr2: 2140829-2146678
AT2G05710 0.5kb upstream 0.5kb upstream 500   false Chr2: 2140829-2141328
AT2G05710 0.5kb downstream 0.5kb downstream 5850   true Chr2: 2141329-2147178
AT2G05710 0.5kb downstream 0.5kb downstream 500   false Chr2: 2146679-2147178
AT2G05710 1.0kb upstream 1.0kb upstream 6350   true Chr2: 2140329-2146678
AT2G05710 1.0kb upstream 1.0kb upstream 1000   false Chr2: 2140329-2141328
AT2G05710 1.0kb downstream 1.0kb downstream 6350   true Chr2: 2141329-2147678
AT2G05710 1.0kb downstream 1.0kb downstream 1000   false Chr2: 2146679-2147678
AT2G05710 3.0kb upstream 3.0kb upstream 8350   true Chr2: 2138329-2146678
AT2G05710 3.0kb upstream 3.0kb upstream 3000   false Chr2: 2138329-2141328
AT2G05710 3.0kb downstream 3.0kb downstream 8350   true Chr2: 2141329-2149678
AT2G05710 3.0kb downstream 3.0kb downstream 3000   false Chr2: 2146679-2149678

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7 Pathways

Data Source: KEGG

Identifier Name
00020 Citrate cycle (TCA cycle)
01100 Metabolic pathways
01110 Biosynthesis of secondary metabolites
01200 Carbon metabolism
01230 Biosynthesis of amino acids
00630 Glyoxylate and dicarboxylate metabolism
01210 2-Oxocarboxylic acid metabolism

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12 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from TIGR GO annotations assigned by TIGR Arabidopsis annotation effort 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139