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Gene : HUB1 A. thaliana

Gene ID  ? AT2G44950
Brief Description  histone mono-ubiquitination 1  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? histone mono-ubiquitination 1 (HUB1); FUNCTIONS IN: ubiquitin-protein ligase activity, protein homodimerization activity, zinc ion binding; INVOLVED IN: in 10 processes; LOCATED IN: mitochondrion, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: histone mono-ubiquitination 2 (TAIR:AT1G55250.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? The gene encodes one of two orthologous E3 ubiquitin ligases in Arabidopsis that are involved in monoubiquitination of histone H2B.  Source: TAIR, Jun 30, 2015.
Name  ? histone mono-ubiquitination 1
  • synonyms:
  • RDO4,
  • REDUCED DORMANCY 4

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7 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
role is proposed for chromatin remodeling in seed dormancy by H2B monoubiquitination through HUB1 and HUB2 17329563
Data show that HUB1 is a functional homolog of the human and yeast BRE1 proteins, adn suggest that it mediates gene activation and cell cycle regulation through chromatin modifications. 17329565
HUB1 upregulates the expression of FLC, and interacts with UBC1 and UBC2 to repress flowering. 18980658
Results describe the role of the Arabidopsis thaliana RING E3 ligase, HISTONE MONOUBIQUITINATION1 (HUB1) in disease resistance. 19286969
Double mutants between hub1-1 and elongata (elo) showed an embryo-lethal phenotype, indicating a synergistic genetic interaction. 22762858
Data showed that parameters for plant fitness are altered in HUB1 mutant and overexpression lines, suggesting that the histone H2B monoubiquitination status affects plant fitness. 23073007
Two RING E3 ligases, HISTONE MONOUBIQUITINATION 1 and 2 (HUB1 and HUB2), play a role in the selective transcriptional activation of four cuticle biosynthesis genes in Arabidopsis thaliana. 24319075

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT2G44950 0.5kb upstream 0.5kb upstream 6978   true Chr2: 18542175-18549152
AT2G44950 0.5kb upstream 0.5kb upstream 500   false Chr2: 18548653-18549152
AT2G44950 0.5kb downstream 0.5kb downstream 6978   true Chr2: 18541675-18548652
AT2G44950 0.5kb downstream 0.5kb downstream 500   false Chr2: 18541675-18542174
AT2G44950 1.0kb upstream 1.0kb upstream 7478   true Chr2: 18542175-18549652
AT2G44950 1.0kb upstream 1.0kb upstream 1000   false Chr2: 18548653-18549652
AT2G44950 1.0kb downstream 1.0kb downstream 7478   true Chr2: 18541175-18548652
AT2G44950 1.0kb downstream 1.0kb downstream 1000   false Chr2: 18541175-18542174
AT2G44950 3.0kb upstream 3.0kb upstream 9478   true Chr2: 18542175-18551652
AT2G44950 3.0kb upstream 3.0kb upstream 3000   false Chr2: 18548653-18551652
AT2G44950 3.0kb downstream 3.0kb downstream 9478   true Chr2: 18539175-18548652
AT2G44950 3.0kb downstream 3.0kb downstream 3000   false Chr2: 18539175-18542174

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0 Pathways

Data Source: KEGG

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10 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from TAIR GO annotations assigned by TAIR 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139