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Gene : RACK1C_AT A. thaliana

Gene ID  ? AT3G18130
Brief Description  receptor for activated C kinase 1C  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? receptor for activated C kinase 1C (RACK1C_AT); FUNCTIONS IN: nucleotide binding; INVOLVED IN: shoot development, root development; LOCATED IN: nucleolus, heterotrimeric G-protein complex; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: receptor for activated C kinase 1B (TAIR:AT1G48630.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes a protein with similarity to mammalian RACKs. RACKs function to shuttle activated protein kinase C to different subcellular sites and may also function as a scaffold through physical interactions with other proteins. RACK1C has no phenotype on its own and probably acts redundantly with RACK1A and RACK1B.  Source: TAIR, Jun 30, 2015.
Name  ? receptor for activated C kinase 1C
  • synonyms:
  • receptor for activated C kinase 1C,
  • RACK1C

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7 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
The first crystal structure of a RACK1 protein, RACK1 isoform A from Arabidopsis thaliana, at 2.4 A resolution is presented. 18715992
RACK1C (At3g18130) is functionally equivalent to RACK1A, and is positively regulated by other RACK1 genes. 18947417
RACK1 genes act redundantly to negatively regulate abscisic acid responses during seed germination and early seedling development 19584117
An enhanced effect on ABA hypersensitivity was observed between rack1a and gpa1 or agb1 mutants in the ABA inhibition of cotyledon greening and root growth. RACK1 and AGB1 may not physically interact with each other. 19651700
RACK1 may be required for normal production of 60S and 80S ribosomes and that its action in these processes may be regulated by abscissic acid. [RACK1C] 21098678
Receptor for activated C kinase 1C, a WD40 repeat protein, was up-regulated in the cbl1 null mutant, and two rack1c mutant lines showed decreased tolerance to salt stress, suggesting that RACK1C plays a role in salt stress resistance. 22002954
These results indicate the intertwined structure of a relatively small and stable protein core and the remaining regions of different levels of flexibility. 24591271

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT3G18130 0.5kb upstream 0.5kb upstream 2174   true Chr3: 6210878-6213051
AT3G18130 0.5kb upstream 0.5kb upstream 500   false Chr3: 6212552-6213051
AT3G18130 0.5kb downstream 0.5kb downstream 2174   true Chr3: 6210378-6212551
AT3G18130 0.5kb downstream 0.5kb downstream 500   false Chr3: 6210378-6210877
AT3G18130 1.0kb upstream 1.0kb upstream 2674   true Chr3: 6210878-6213551
AT3G18130 1.0kb upstream 1.0kb upstream 1000   false Chr3: 6212552-6213551
AT3G18130 1.0kb downstream 1.0kb downstream 2674   true Chr3: 6209878-6212551
AT3G18130 1.0kb downstream 1.0kb downstream 1000   false Chr3: 6209878-6210877
AT3G18130 3.0kb upstream 3.0kb upstream 4674   true Chr3: 6210878-6215551
AT3G18130 3.0kb upstream 3.0kb upstream 3000   false Chr3: 6212552-6215551
AT3G18130 3.0kb downstream 3.0kb downstream 4674   true Chr3: 6207878-6212551
AT3G18130 3.0kb downstream 3.0kb downstream 3000   false Chr3: 6207878-6210877

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Data Source: KEGG

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11 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from TIGR GO annotations assigned by TIGR Arabidopsis annotation effort 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139