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Gene : MSH2 A. thaliana

Gene ID  ? AT3G18524
Brief Description  MUTS homolog 2  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? MUTS homolog 2 (MSH2); FUNCTIONS IN: damaged DNA binding, protein binding, mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair, negative regulation of reciprocal meiotic recombination; LOCATED IN: plasma membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695), DNA mismatch repair protein, MSH2 (InterPro:IPR011184); BEST Arabidopsis thaliana protein match is: homolog of DNA mismatch repair protein MSH3 (TAIR:AT4G25540.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes a DNA mismatch repair homolog of human MutS gene, MSH6. MSH2 is involved in maintaining genome stability and repressing recombination of mismatched heteroduplexes.There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2 has different binding specificity to different mismatches in combination with MSH3, MSH6, or MSH7.  Source: TAIR, Jun 30, 2015.
Name  ? MUTS homolog 2
  • synonyms:
  • ATMSH2

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3 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
reported that AtMSH2 has a broad range of anti-recombination effects: it suppresses recombination between divergent direct repeats in somatic cells or between homologues from different ecotypes during meiosis 16311517
The contribution of MutSalpha (MSH2-MSH6) to ultraviolet-induced DNA lesion repair and cell cycle regulation was investigated. 21307385
The expression of AtMutSgamma (MSH7 and MSH2) in Saccharomyces cerevisiae suggest that AtMutSgamma affects yeast genomic stability by recognizing specific mismatches. 23380521

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT3G18524 0.5kb upstream 0.5kb upstream 5245   true Chr3: 6367941-6373185
AT3G18524 0.5kb upstream 0.5kb upstream 500   false Chr3: 6372686-6373185
AT3G18524 0.5kb downstream 0.5kb downstream 5245   true Chr3: 6367441-6372685
AT3G18524 0.5kb downstream 0.5kb downstream 500   false Chr3: 6367441-6367940
AT3G18524 1.0kb upstream 1.0kb upstream 5745   true Chr3: 6367941-6373685
AT3G18524 1.0kb upstream 1.0kb upstream 1000   false Chr3: 6372686-6373685
AT3G18524 1.0kb downstream 1.0kb downstream 5745   true Chr3: 6366941-6372685
AT3G18524 1.0kb downstream 1.0kb downstream 1000   false Chr3: 6366941-6367940
AT3G18524 3.0kb upstream 3.0kb upstream 7745   true Chr3: 6367941-6375685
AT3G18524 3.0kb upstream 3.0kb upstream 3000   false Chr3: 6372686-6375685
AT3G18524 3.0kb downstream 3.0kb downstream 7745   true Chr3: 6364941-6372685
AT3G18524 3.0kb downstream 3.0kb downstream 3000   false Chr3: 6364941-6367940

Proteins

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Function

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1 Pathways

Data Source: KEGG

Identifier Name
03430 Mismatch repair

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11 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from RefGenome GO annotations assigned by RefGenome 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139