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Gene : MKK5 A. thaliana

Gene ID  ? AT3G21220
Brief Description  MAP kinase kinase 5  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? MAP kinase kinase 5 (MKK5); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: mitogen-activated protein kinase kinase 4 (TAIR:AT1G51660.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes a mitogen-activated kinase kinase, dual specific protein kinase that is expressed in vegetative tissues and floral buds. Involved in innate immunity. This protein activates MPK3/MPK6 and early-defense genes redundantly with MKK4.In plants with both MKK5 and MKK6 levels reduced by RNAi plants, floral organs do not abscise suggestion a role for both proteins in mediating floral organ abscission.  Source: TAIR, Jun 30, 2015.
Name  ? MAP kinase kinase 5
  • synonyms:
  • ATMEK5,
  • MEK5,
  • MAP2K_A,
  • ATMKK5,

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6 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
MKK5 is a key regulator of stomatal development and patterning. 17259259
MKK5 functions both in ozone-induced activation of MPK3 and MPK6 and in integrating reactive oxygen species homeostasis during ozone stress. 19820329
Results suggest that the YDA-MKK4/MKK5-MPK3/MPK6 cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs. 23263767
Data indicate that in the MKK5-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 as well as the activation of MKK5 activity were completely arrested. 23677921
our data indicate that EDR1 physically associates with MKK4/MKK5 and negatively regulates the MAPK cascade to fine-tune plant innate immunity. 24830651
Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments. Another kinase, MPK6, was also involved in the MKK5-mediated iron superoxide dismutase (FSD) signalling pathway in salt stress. 26136265


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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT3G21220 0.5kb upstream 0.5kb upstream 3395   true Chr3: 7445104-7448498
AT3G21220 0.5kb upstream 0.5kb upstream 500   false Chr3: 7445104-7445603
AT3G21220 0.5kb downstream 0.5kb downstream 3395   true Chr3: 7445604-7448998
AT3G21220 0.5kb downstream 0.5kb downstream 500   false Chr3: 7448499-7448998
AT3G21220 1.0kb upstream 1.0kb upstream 3895   true Chr3: 7444604-7448498
AT3G21220 1.0kb upstream 1.0kb upstream 1000   false Chr3: 7444604-7445603
AT3G21220 1.0kb downstream 1.0kb downstream 3895   true Chr3: 7445604-7449498
AT3G21220 1.0kb downstream 1.0kb downstream 1000   false Chr3: 7448499-7449498
AT3G21220 3.0kb upstream 3.0kb upstream 5895   true Chr3: 7442604-7448498
AT3G21220 3.0kb upstream 3.0kb upstream 3000   false Chr3: 7442604-7445603
AT3G21220 3.0kb downstream 3.0kb downstream 5895   true Chr3: 7445604-7451498
AT3G21220 3.0kb downstream 3.0kb downstream 3000   false Chr3: 7448499-7451498


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1 Pathways

Data Source: KEGG

Identifier Name
04626 Plant-pathogen interaction

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12 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from GOC GO annotations assigned by the GO Consortium 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139