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Gene : SGT1B A. thaliana

Gene ID  ? AT4G11260
Brief Description  phosphatase-like protein  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? SGT1B; FUNCTIONS IN: protein binding; INVOLVED IN: in 6 processes; LOCATED IN: SCF ubiquitin ligase complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: CS-like domain (InterPro:IPR007052), Tetratricopeptide-like helical (InterPro:IPR011990), SGS (InterPro:IPR007699), Tetratricopeptide repeat-containing (InterPro:IPR013026), HSP20-like chaperone (InterPro:IPR008978), Tetratricopeptide repeat (InterPro:IPR019734), CS domain (InterPro:IPR017447); BEST Arabidopsis thaliana protein match is: phosphatase-related (TAIR:AT4G23570.2).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Functions in plant disease resistance signaling, SCF(TIR1) mediated degradation of Aux/IAA proteins and HSP90 mediated degradation of R resistance proteins. AtSGT1a and AtSGT1b are functionally redundant in the resistance to pathogenes. AtSGT1b was more highly expressed than AtSGT1. The N-terminal TPR domain of AtSGT1a reduces the steady-state level of Arabidopsis SGT1 proteins whereas the same domain from AtSGT1b enhances SGT1 accumulation. The TPR domain is dispensable for SGT1 resistance.  Source: TAIR, Jun 30, 2015.

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7 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
SGT1b antagonizes RAR1 to negatively regulate R protein accumulation before infection, and SGT1b has a RAR1-independent function that regulates programmed cell death during infection [SGT1b] 15976272
Biochemical reconstitution experiments suggest that RAR1 may function to enhance the SGT1-HSP90 interaction by promoting ternary complex formation. 18032631
Genetic analysis revealed that ssi4-induced H(2)O(2) accumulation and spontaneous cell death require RAR1, whereas ssi4-mediated stunting is dependent on SGT1b. 18052881
Data show that intact C-terminal SGT1-specific (SGS) domain that is required for all known SGT1b functions in immunity and development is needed for HSC70 interaction and for the nuclear accumulation of SGT1b. 18065690
SGT1b has a role in disease resistance against Fusarium culmorum. 19140951
The induction of defence responses and disease resistance to X. campestris pv. campestris strain 8004 requires NDR1 , RAR1 and SGT1b, suggesting that effector-triggered immunity plays a large role in resistance to this strain. 21029323
This study showed that increased temperature promotes rapid accumulation of the TIR1 auxin co-receptor, an effect that is dependent on the molecular chaperone HSP90, and that HSP90 and SGT1 integrate temperature and auxin signaling.[SGT1] 26728313

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT4G11260 0.5kb upstream 0.5kb upstream 3229   true Chr4: 6851184-6854412
AT4G11260 0.5kb upstream 0.5kb upstream 500   false Chr4: 6853913-6854412
AT4G11260 0.5kb downstream 0.5kb downstream 3229   true Chr4: 6850684-6853912
AT4G11260 0.5kb downstream 0.5kb downstream 500   false Chr4: 6850684-6851183
AT4G11260 1.0kb upstream 1.0kb upstream 3729   true Chr4: 6851184-6854912
AT4G11260 1.0kb upstream 1.0kb upstream 1000   false Chr4: 6853913-6854912
AT4G11260 1.0kb downstream 1.0kb downstream 3729   true Chr4: 6850184-6853912
AT4G11260 1.0kb downstream 1.0kb downstream 1000   false Chr4: 6850184-6851183
AT4G11260 3.0kb upstream 3.0kb upstream 5729   true Chr4: 6851184-6856912
AT4G11260 3.0kb upstream 3.0kb upstream 3000   false Chr4: 6853913-6856912
AT4G11260 3.0kb downstream 3.0kb downstream 5729   true Chr4: 6848184-6853912
AT4G11260 3.0kb downstream 3.0kb downstream 3000   false Chr4: 6848184-6851183

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1 Pathways

Data Source: KEGG

Identifier Name
04626 Plant-pathogen interaction

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12 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from TAIR GO annotations assigned by TAIR 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139