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Gene : CCS52A2 A. thaliana

Gene ID  ? AT4G11920
Brief Description  cell cycle switch protein 52 A2  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? cell cycle switch protein 52 A2 (CCS52A2); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: FIZZY-related 2 (TAIR:AT4G22910.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes a putative activator of the anaphase-promoting complex/cyclosome. Promotes exit from the cell cycle and entry into the endocycle leading to endoreduplication. Mutation of this gene results in abnormal shoot apical meristem development. It likely regulates the development of meristems by indirectly interacting with WUS and CLV3.  Source: TAIR, Jun 30, 2015.
Name  ? cell cycle switch protein 52 A2
  • synonyms:
  • FIZZY-RELATED 1,
  • FZR1

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5 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
the atypical E2F transcription factor E2Fe/DEL1 controls the expression of the CDH1/FZR orthologous CCS52A2 gene from Arabidopsis thaliana 18787127
CCS52A2 acts directly in the distal region of the root meristem to control identity of the quiescent center (QC) cells and stem cell maintenance. 19553203
Studies indicate that the APC is composed of at least 11 subunits and associates with additional regulatory activators CDC20/CCS52 during mitosis and interphase cycles. 21087491
The CCS52A2 gene is a mediator that functions together with meristematic genes to regulate meristem organization. 22873486
Findings support both complementary and dose-dependent actions for the Arabidopsis CCS52A isoforms in plant development and demonstrate that elevated ectopic CCS52A expression positively correlates with organ size, opening a route to higher biomass production. [CCS52A2] 23528034

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT4G11920 0.5kb upstream 0.5kb upstream 3685   true Chr4: 7160243-7163927
AT4G11920 0.5kb upstream 0.5kb upstream 500   false Chr4: 7163428-7163927
AT4G11920 0.5kb downstream 0.5kb downstream 3685   true Chr4: 7159743-7163427
AT4G11920 0.5kb downstream 0.5kb downstream 500   false Chr4: 7159743-7160242
AT4G11920 1.0kb upstream 1.0kb upstream 4185   true Chr4: 7160243-7164427
AT4G11920 1.0kb upstream 1.0kb upstream 1000   false Chr4: 7163428-7164427
AT4G11920 1.0kb downstream 1.0kb downstream 4185   true Chr4: 7159243-7163427
AT4G11920 1.0kb downstream 1.0kb downstream 1000   false Chr4: 7159243-7160242
AT4G11920 3.0kb upstream 3.0kb upstream 6185   true Chr4: 7160243-7166427
AT4G11920 3.0kb upstream 3.0kb upstream 3000   false Chr4: 7163428-7166427
AT4G11920 3.0kb downstream 3.0kb downstream 6185   true Chr4: 7157243-7163427
AT4G11920 3.0kb downstream 3.0kb downstream 3000   false Chr4: 7157243-7160242

Proteins

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Function

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1 Pathways

Data Source: KEGG

Identifier Name
04120 Ubiquitin mediated proteolysis

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12 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from TIGR GO annotations assigned by TIGR Arabidopsis annotation effort 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139