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Gene : LOI1 A. thaliana

Gene ID  ? AT4G14850
Brief Description  Pentatricopeptide repeat (PPR) superfamily protein  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? lovastatin insensitive 1 (LOI1); CONTAINS InterPro DOMAIN/s: Pentatricopeptide repeat (InterPro:IPR002885); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT5G09950.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes a pentatricopeptide (PPR) protein that binds single-stranded RNA. The N-terminal portion of the protein can localize to the mitochondria. Mutations in this gene make plants less sensitive to inhibitors of the MEP and MVA pathways of isoprenoid biosynthesis and increase the activity of HMG CoA reductase.  Source: TAIR, Jun 30, 2015.
Name  ? lovastatin insensitive 1
  • synonyms:
  • mitochondrial RNA editing factor 11,
  • MEF11

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4 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
Identification of RNA editing factor MEF11 as the loi1 gene product 19919573
MEF11 is a nuclear encoded gene which is involved in RNA editing of the three sites cox3-422, nad4-124 and ccb203-344 in Arabidopsis thaliana mitochondria. [MEF11] 19919573
report that LOI1 is an essential factor for RNA editing of three mitochondrial genes, nad4, ccb203 and cox3. 19929879
These observations suggest that the enzymatic activity or its recruitment is not compromised by the alteration of the C-terminus of MEF11. 20436293


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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT4G14850 0.5kb upstream 0.5kb upstream 3054   true Chr4: 8513307-8516360
AT4G14850 0.5kb upstream 0.5kb upstream 500   false Chr4: 8513307-8513806
AT4G14850 0.5kb downstream 0.5kb downstream 3054   true Chr4: 8513807-8516860
AT4G14850 0.5kb downstream 0.5kb downstream 500   false Chr4: 8516361-8516860
AT4G14850 1.0kb upstream 1.0kb upstream 3554   true Chr4: 8512807-8516360
AT4G14850 1.0kb upstream 1.0kb upstream 1000   false Chr4: 8512807-8513806
AT4G14850 1.0kb downstream 1.0kb downstream 3554   true Chr4: 8513807-8517360
AT4G14850 1.0kb downstream 1.0kb downstream 1000   false Chr4: 8516361-8517360
AT4G14850 3.0kb upstream 3.0kb upstream 5554   true Chr4: 8510807-8516360
AT4G14850 3.0kb upstream 3.0kb upstream 3000   false Chr4: 8510807-8513806
AT4G14850 3.0kb downstream 3.0kb downstream 5554   true Chr4: 8513807-8519360
AT4G14850 3.0kb downstream 3.0kb downstream 3000   false Chr4: 8516361-8519360


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0 Pathways

Data Source: KEGG

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RNA-seq Expression


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9 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from UniProt GO annotations assigned by UniProt 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016