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Gene : IRT1 A. thaliana

Gene ID  ? AT4G19690
Brief Description  iron-regulated transporter 1  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? iron-regulated transporter 1 (IRT1); FUNCTIONS IN: manganese ion transmembrane transporter activity, zinc ion transmembrane transporter activity, cadmium ion transmembrane transporter activity, copper uptake transmembrane transporter activity, iron ion transmembrane transporter activity; INVOLVED IN: in 11 processes; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Zinc/iron permease (InterPro:IPR003689); BEST Arabidopsis thaliana protein match is: iron regulated transporter 2 (TAIR:AT4G19680.2).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? The gene encodes Fe2 transporter protein. It is a member of the Zrt/Irt-like protein (ZIP) family of transporters. AtIRT1 has broad specificity for divalent heavy metals, mediating the transport of zinc, manganese, cobalt and cadmium under Fe-deficient conditions. IRT1 is monoubiquitinated to promote endocytic trafficking.  Source: TAIR, Jun 30, 2015.
Name  ? iron-regulated transporter 1
  • synonyms:
  • ATIRT1

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14 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
Although ferrous ions and other IRT1-transported metal ions do not bind very tightly, the Histidine-rich sequence has a very high entropy-driven affinity for Fe3+, which may have biological significance. 17029360
ferric-chelate reductase FRO2 and ferrous-transporter IRT1 are the targets of the three transcription factors and the transcription of FRO2 and IRT1 is directly regulated by a complex of FIT/AtbHLH38 or FIT/AtbHLH39. 18268542
Expression of each of the IRT1 variants in plants from the 35S promoter revealed that K146 or K171 is required for iron-induced protein turnover, and 35S-IRT1K146R,K171R plants contain higher levels of iron compared to 35S-IRT1 and wild type 18305211
Results show that IRT2 appears strictly co-regulated with FRO2 and IRT1, supporting the view that IRT2 is an integral component of the root response to iron deficiency in root epidermal cells. 19252923
Acidification capacity varied among Arabidopsis accessions and was associated with a high induction of AHA2 and IRT1... 19549134
Application of the lipoxygenase inhibitor ibuprofene to plants caused an up-regulation of IRT1 gene expression. 21334215
IRT1 and FRO2 genes are upregulated under iron starvation. 21426424
These data suggest a model in which monoubiquitin-dependent internalization/sorting and turnover keep the plasma membrane pool of IRT1 low to ensure proper iron uptake and to prevent metal toxicity. 21628566
AtIRT1 transports nicekl (Ni(2+)) in roots, and strongly suggest that Ni accumulation is further accelerated by AtIRT1 that is expressed in response to excess Ni. 21742768
Data indicate that steady-state mRNA abundance for three representative Fe homeostasis genes, IRT1, bHLH39, and FER1, oscillated in light/dark (LD) cycles or warm/cold environmental cycles. 23250624
IDF1 directly regulates IRT1 degradation through its RING-type E3 ligase activity. 23995086
Our results reveal a role of SNX1 for the correct trafficking of IRT1 and, thus, for modulating the activity of the iron uptake machinery 24596241
This work establishes a functional link between the dynamics and the lateral polarity of IRT1 and the transport of its substrates, and identifies a molecular mechanism driving polar localization of a cell surface protein in plants. 24843126
role of IRT1 in iron uptake 25778985


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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT4G19690 0.5kb upstream 0.5kb upstream 2172   true Chr4: 10706844-10709015
AT4G19690 0.5kb upstream 0.5kb upstream 500   false Chr4: 10706844-10707343
AT4G19690 0.5kb downstream 0.5kb downstream 2172   true Chr4: 10707344-10709515
AT4G19690 0.5kb downstream 0.5kb downstream 500   false Chr4: 10709016-10709515
AT4G19690 1.0kb upstream 1.0kb upstream 2672   true Chr4: 10706344-10709015
AT4G19690 1.0kb upstream 1.0kb upstream 1000   false Chr4: 10706344-10707343
AT4G19690 1.0kb downstream 1.0kb downstream 2672   true Chr4: 10707344-10710015
AT4G19690 1.0kb downstream 1.0kb downstream 1000   false Chr4: 10709016-10710015
AT4G19690 3.0kb upstream 3.0kb upstream 4672   true Chr4: 10704344-10709015
AT4G19690 3.0kb upstream 3.0kb upstream 3000   false Chr4: 10704344-10707343
AT4G19690 3.0kb downstream 3.0kb downstream 4672   true Chr4: 10707344-10712015
AT4G19690 3.0kb downstream 3.0kb downstream 3000   false Chr4: 10709016-10712015


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Data Source: KEGG

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10 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from InterPro    
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139