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Gene : MEK1 A. thaliana

Gene ID  ? AT4G26070
Brief Description  MAP kinase/ ERK kinase 1  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? MAP kinase/ ERK kinase 1 (MEK1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: MAP kinase kinase 2 (TAIR:AT4G29810.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Member of MAP Kinase Kinase. Likely functions in a stress-activated MAPK pathway. Can phosphorylate the MAPK AtMPK4, in response to stress. Gets phosphorylated by MEKK1 in response to wounding.  Source: TAIR, Jun 30, 2015.
Name  ? MAP kinase/ ERK kinase 1
  • synonyms:
  • ATMEK1,
  • MKK1

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12 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
An analysis of the interation of MEKK1 and MEK1 in response to wounding stress in A. thaliana seedlings is presented. 16211390
This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence. 17059410
These results suggest that the formation of SUMO-1 foci is regulated by the MEK-ERK pathway and may induce apoptosis. 17284251
AtMEK1 is a crucial mediator in plant stress signal transduction. 17728292
double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 and mpk4 mutants 18599650
Activation of MPK4 by flg22 is impaired in the mkk1 mkk2 double mutants, suggesting that MKK1 and MKK2 function together with MPK4 and MEKK1 in a MAP kinase cascade to negatively regulate innate immune responses in plants. 18982020
SDF-1alpha acts through CXCR4 to activate MEK and ERK, which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activations of alphavbeta3 integrins and contributing the migration of human osteosarcoma cells. 19496172
ETS1 is probably mediating high CIP2A expression in human cancers with increased EGFR-MEK1/2-ERK pathway activity 21445343
miR-1826 plays an important role as tumor suppressor via CTNNB1/MEK1/VEGFC downregulation in bladder cancer. 22049531
Data suggest that the MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates MEKK2 and activation of MEKK2 triggers SUMM2-mediated immune responses. 22643122
AtMKK1 mutant plants tolerated elevated levels of salt during both germination and adulthood. 23511202
Data indicate that MEKK2 is required for the mekk1, mkk1 mkk2, and mpk4 autoimmune phenotypes. 23695980


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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT4G26070 0.5kb upstream 0.5kb upstream 2962   true Chr4: 13216975-13219936
AT4G26070 0.5kb upstream 0.5kb upstream 500   false Chr4: 13216975-13217474
AT4G26070 0.5kb downstream 0.5kb downstream 2962   true Chr4: 13217475-13220436
AT4G26070 0.5kb downstream 0.5kb downstream 500   false Chr4: 13219937-13220436
AT4G26070 1.0kb upstream 1.0kb upstream 3462   true Chr4: 13216475-13219936
AT4G26070 1.0kb upstream 1.0kb upstream 1000   false Chr4: 13216475-13217474
AT4G26070 1.0kb downstream 1.0kb downstream 3462   true Chr4: 13217475-13220936
AT4G26070 1.0kb downstream 1.0kb downstream 1000   false Chr4: 13219937-13220936
AT4G26070 3.0kb upstream 3.0kb upstream 5462   true Chr4: 13214475-13219936
AT4G26070 3.0kb upstream 3.0kb upstream 3000   false Chr4: 13214475-13217474
AT4G26070 3.0kb downstream 3.0kb downstream 5462   true Chr4: 13217475-13222936
AT4G26070 3.0kb downstream 3.0kb downstream 3000   false Chr4: 13219937-13222936


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0 Pathways

Data Source: KEGG

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11 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from GOC GO annotations assigned by the GO Consortium 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139