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Gene : AUR1 A. thaliana

Gene ID  ? AT4G32830
Brief Description  ataurora1  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? ataurora1 (AUR1); CONTAINS InterPro DOMAIN/s: Spindle assembly checkpoint kinase (InterPro:IPR020663), Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: ataurora2 (TAIR:AT2G25880.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes a member of a family of Ser/Thr kinases whose activities peak during cell division. Transcripts are abundant in tissues rich in dividing cells like roots and flowers but are low or absent in fully expanded leaves and stems. In interphase cells, the protein is predominantly nuclear. During mitosis, the protein associates with plant-specific cytoskeletal structures (preprophase band, phragmoplast, nascent cell plate) that are necessary for cytokinesis as well as with the microtubule spindle. It specifically phosphorylates Ser10 of histone H3 and colocalizes with phosphorylated histone H3 during mitosis.  Source: TAIR, Jun 30, 2015.
Name  ? ataurora1
  • synonyms:
  • AtAUR1,
  • ataurora1

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5 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
Aurora kinase AtAUR1 localized at the nuclear membrane in interphase and located in mitotic spindles and cell plates during cell division. 16028112
AtAurora1 in vivo kinase activity was inhibited by hesperadin which also inhibited histone H3S10 phosphorylation. 19582900
a central role for AUR1 kinase in regulating formative division plane orientation throughout development 22045917
AtAurora1 kinase may function to phosphorylate substrates that are critical to the spatiotemporal regulation of acentrosomal microtubule formation and organization. 22150830
Aurora kinases play an essential role in the monitoring of meiosis in plants. 25146886

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT4G32830 0.5kb upstream 0.5kb upstream 2923   true Chr4: 15841943-15844865
AT4G32830 0.5kb upstream 0.5kb upstream 500   false Chr4: 15841943-15842442
AT4G32830 0.5kb downstream 0.5kb downstream 2923   true Chr4: 15842443-15845365
AT4G32830 0.5kb downstream 0.5kb downstream 500   false Chr4: 15844866-15845365
AT4G32830 1.0kb upstream 1.0kb upstream 3423   true Chr4: 15841443-15844865
AT4G32830 1.0kb upstream 1.0kb upstream 1000   false Chr4: 15841443-15842442
AT4G32830 1.0kb downstream 1.0kb downstream 3423   true Chr4: 15842443-15845865
AT4G32830 1.0kb downstream 1.0kb downstream 1000   false Chr4: 15844866-15845865
AT4G32830 3.0kb upstream 3.0kb upstream 5423   true Chr4: 15839443-15844865
AT4G32830 3.0kb upstream 3.0kb upstream 3000   false Chr4: 15839443-15842442
AT4G32830 3.0kb downstream 3.0kb downstream 5423   true Chr4: 15842443-15847865
AT4G32830 3.0kb downstream 3.0kb downstream 3000   false Chr4: 15844866-15847865

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0 Pathways

Data Source: KEGG

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10 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from GOC GO annotations assigned by the GO Consortium 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139