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Gene : CTR1 A. thaliana

Gene ID  ? AT5G03730
Brief Description  Protein kinase superfamily protein  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? CONSTITUTIVE TRIPLE RESPONSE 1 (CTR1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT4G24480.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Homologous to the RAF family of serine/threonine protein kinases. Negative regulator in the ethylene signal transduction pathway. Interacts with the putative ethylene receptors ETR1 and ERS. Constitutively expressed.  Source: TAIR, Jun 30, 2015.
  • synonyms:
  • SIS1,
  • AtCTR1

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13 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
It was shown that phosphatidic acid (PA) binds CTR1 and inhibits its kinase activity; Subsequent deletion analysis of CTR1's kinase domain revealed a novel PA-binding region at the C-terminus of the kinase. 18000017
Data demonstrate that CTR1 acts as a concentration-dependent repressor of a biosynthesis-dependent auxin gradient that modulates planar polarity in the root tip. 19448626
Results report the crystallization of the C-terminal protein kinase domain of CTR1 in its wild-type form and as a kinase-dead mutant, and show that wild-type crystals diffracted to 3 A resolution and the kinase-dead mutant to 2.5 A resolution. 21206040
Together with a front-to-front activation interface, the active protein kinase dimers thereby engage in interactions that promote CTR1-mediated cross talk between ethylene receptor clusters. 22155294
The roles of CTR1 and RTE1 in ETR1 N-terminal signaling, were evaluated. 22566492
Possible modulations of ETR1 N-terminal signaling with docking of CTR1 on the ETR1 HK domain, is reported. 22902695
Phosphorylation of EIN2 by CTR1 prevents EIN2 from signaling in the absence of ethylene, whereas inhibition of CTR1 upon ethylene perception is a signal for cleavage and nuclear localization of the EIN2 C terminus. 23132950
Genetic studies unveiled the existence of are1-1 mutation in the ctr1-1 mutant, as a second-site modifier which confers root-specific ethylene-resistance. 23740431
Protein phosphorylation plays a key role in ethylene signaling, which is mediated by the activities of ethylene receptors, CTR1, and RCN1. 24043427
Ethylene receptor/CTR1 signaling is regulated by ethylene in Arabidopsis thaliana 25814663
The dark submergence-sensitive phenotypes of loh mutants were rescued by a ctr1-1 mutation. Thus, our findings demonstrate that unsaturation of VLC ceramides is a protective strategy for hypoxic tolerance in Arabidopsis 25822663
Ethylene (ET) affects auxin signaling through the central regulator CTR1 and that fungal-derived compounds, such as indole-3-acetic acid and indole-3-acetaldehyde, induce MPK6 activity. 26067203
the roles of CTR1-related proteins appear to have functionally diversified during land-plant evolution. 26243614


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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT5G03730 0.5kb upstream 0.5kb upstream 5990   true Chr5: 974360-980349
AT5G03730 0.5kb upstream 0.5kb upstream 500   false Chr5: 979850-980349
AT5G03730 0.5kb downstream 0.5kb downstream 5990   true Chr5: 973860-979849
AT5G03730 0.5kb downstream 0.5kb downstream 500   false Chr5: 973860-974359
AT5G03730 1.0kb upstream 1.0kb upstream 6490   true Chr5: 974360-980849
AT5G03730 1.0kb upstream 1.0kb upstream 1000   false Chr5: 979850-980849
AT5G03730 1.0kb downstream 1.0kb downstream 6490   true Chr5: 973360-979849
AT5G03730 1.0kb downstream 1.0kb downstream 1000   false Chr5: 973360-974359
AT5G03730 3.0kb upstream 3.0kb upstream 8490   true Chr5: 974360-982849
AT5G03730 3.0kb upstream 3.0kb upstream 3000   false Chr5: 979850-982849
AT5G03730 3.0kb downstream 3.0kb downstream 8490   true Chr5: 971360-979849
AT5G03730 3.0kb downstream 3.0kb downstream 3000   false Chr5: 971360-974359


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1 Pathways

Data Source: KEGG

Identifier Name
04075 Plant hormone signal transduction

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12 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from UniProt GO annotations assigned by UniProt 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139