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Gene : PDK1 A. thaliana

Gene ID  ? AT5G04510
Brief Description  3'-phosphoinositide-dependent protein kinase 1  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? 3'-phosphoinositide-dependent protein kinase 1 (PDK1); FUNCTIONS IN: 3-phosphoinositide-dependent protein kinase activity, protein binding, phosphoinositide binding, protein kinase activity, kinase activity; INVOLVED IN: positive regulation of protein kinase activity; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Serine/threonine-protein kinase-1, 3-phosphoinositide dependent (InterPro:IPR015746), Protein kinase, catalytic domain (InterPro:IPR000719), Pleckstrin homology-type (InterPro:IPR011993); BEST Arabidopsis thaliana protein match is: 3-phosphoinositide-dependent protein kinase (TAIR:AT3G10540.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes 3-phosphoinositide-dependent protein kinase that contains pleckstrin homology domain and binds 3-phosphoinositides. It activates the protein kinase AGC2-1 in a phosphatidic acid dependent manner. Phosphorylates S6K1. Interacts with PID, and transphosphorylation by PDK1 increases PID autophosphorylation.  Source: TAIR, Jun 30, 2015.
Name  ? 3'-phosphoinositide-dependent protein kinase 1
  • synonyms:
  • ATPDK1

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4 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
PDK1 undergoes autophosphorylation at several sites; mutation of Ser-276 to Ala resulted in enzyme with no detectable autophosphorylation; other sites important for autophosphorylation &/or activity were Asp-167, Thr-176, & Thr-211 16125835
PDK1 is a potent enhancer of PID activity. 16601102
specific lipid signaling pathways converge on PTI1-2 via the PDK1-OXI1 axis 17040918
Piriformospora indica-stimulated growth response is mediated by a pathway consisting of the PLD-PDK1-OXI1 cascade. 21625539


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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT5G04510 0.5kb upstream 0.5kb upstream 3566   true Chr5: 1286343-1289908
AT5G04510 0.5kb upstream 0.5kb upstream 500   false Chr5: 1286343-1286842
AT5G04510 0.5kb downstream 0.5kb downstream 3566   true Chr5: 1286843-1290408
AT5G04510 0.5kb downstream 0.5kb downstream 500   false Chr5: 1289909-1290408
AT5G04510 1.0kb upstream 1.0kb upstream 4066   true Chr5: 1285843-1289908
AT5G04510 1.0kb upstream 1.0kb upstream 1000   false Chr5: 1285843-1286842
AT5G04510 1.0kb downstream 1.0kb downstream 4066   true Chr5: 1286843-1290908
AT5G04510 1.0kb downstream 1.0kb downstream 1000   false Chr5: 1289909-1290908
AT5G04510 3.0kb upstream 3.0kb upstream 6066   true Chr5: 1283843-1289908
AT5G04510 3.0kb upstream 3.0kb upstream 3000   false Chr5: 1283843-1286842
AT5G04510 3.0kb downstream 3.0kb downstream 6066   true Chr5: 1286843-1292908
AT5G04510 3.0kb downstream 3.0kb downstream 3000   false Chr5: 1289909-1292908


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1 Pathways

Data Source: KEGG

Identifier Name
04931 Insulin resistance

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12 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from InterPro    
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139