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Gene : CAX1 A. thaliana

Gene ID  ? AT2G38170
Brief Description  cation exchanger 1  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? cation exchanger 1 (CAX1); FUNCTIONS IN: calcium:cation antiporter activity, calcium ion transmembrane transporter activity, calcium:hydrogen antiporter activity; INVOLVED IN: cold acclimation, response to salt stress, cellular zinc ion homeostasis, cellular manganese ion homeostasis, calcium ion transport; LOCATED IN: plant-type vacuole membrane, vacuolar membrane, vacuole, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sodium/calcium exchanger membrane region (InterPro:IPR004837), Calcium/proton exchanger superfamily (InterPro:IPR004798), Calcium/proton exchanger (InterPro:IPR004713); BEST Arabidopsis thaliana protein match is: cation exchanger 3 (TAIR:AT3G51860.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes a high affinity vacuolar calcium antiporter. The residue His 338 is critical to Ca2 transport activity. Disruption of CAX1 reduces manganese and zinc of shoot tissue and results in a decrease in the activity of vacuolar V-type proton ATPase.  Source: TAIR, Jun 30, 2015.
Name  ? cation exchanger 1
  • synonyms:
  • RCI4,
  • ATCAX1,
  • RARE COLD INDUCIBLE 4

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13 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
Null CAX1 mutants of Arabidopsis have most of the phenotypes associated with tolerance to serpentine soils, especially altered responses to calcium and magnesium. 15948832
His338 has a role in metal transport activity in the Arabidopsis cation/H+ exchanger CAX1 15994298
The functional roles of calcium exchanger 1 (CAX1), a vacuolar H+/Ca2+ transporter, and the closely related transporter CAX3 are reported. 16055687
plants expressing activated CAX1 variants displayed hypersensitivity to ion imbalances, increased calcium accumulation, heightened concentrations of other minerals, and increased activity of tonoplast-enriched Ca(2+)/H(+) transport 17898422
Interaction between Arabidopsis Ca2+/H+ exchangers CAX1 and CAX3. 19098009
analysis of interactions between CAX protein domains through the use of nonfunctional halves of CAX transporters 19819871
CAX1 has a primary role in Ca accumulation in the leaf mesophyll, and is important in controlling apoplastic [Ca2+], stomatal aperture, and growth. 21258004
The results indicate that the high expression of the sCAX1 gene reduces cytosolic and apoplastic Ca concentrations, affecting plasma membrane structure and leading to blossom-end rot symptom development in the fruit tissue. 21464475
CAX1 and CAX3 mediate a shoot-derived signal that modulates the activity of the root phosphate [P(i)] transporter system, likely in part via posttranslational regulation of PHT1;1 P(i) transporters. 21546457
Shared and unique aspects of CAX1 and CAX3 calcium transport and regulation are demonstrated. 21657244
The role of CAX1 in elemental distribution and abundance in Arabidopsis seed. 22086421
cax1/cax3 mutants have a higher apoplastic pH than the wild type, further supporting the hypothesis that there is a defect in auxin import in the cax mutants. 22932758
Presence of Arabidopsis CAX transporters is important for normal germination and metal homeostasis within the seed. 23071810

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT2G38170 0.5kb upstream 0.5kb upstream 4744   true Chr2: 15989083-15993826
AT2G38170 0.5kb upstream 0.5kb upstream 500   false Chr2: 15993327-15993826
AT2G38170 0.5kb downstream 0.5kb downstream 4744   true Chr2: 15988583-15993326
AT2G38170 0.5kb downstream 0.5kb downstream 500   false Chr2: 15988583-15989082
AT2G38170 1.0kb upstream 1.0kb upstream 5244   true Chr2: 15989083-15994326
AT2G38170 1.0kb upstream 1.0kb upstream 1000   false Chr2: 15993327-15994326
AT2G38170 1.0kb downstream 1.0kb downstream 5244   true Chr2: 15988083-15993326
AT2G38170 1.0kb downstream 1.0kb downstream 1000   false Chr2: 15988083-15989082
AT2G38170 3.0kb upstream 3.0kb upstream 7244   true Chr2: 15989083-15996326
AT2G38170 3.0kb upstream 3.0kb upstream 3000   false Chr2: 15993327-15996326
AT2G38170 3.0kb downstream 3.0kb downstream 7244   true Chr2: 15986083-15993326
AT2G38170 3.0kb downstream 3.0kb downstream 3000   false Chr2: 15986083-15989082

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11 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from UniProt GO annotations assigned by UniProt 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139