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Publication : Structure of archaeal glyoxylate reductase from Pyrococcus horikoshii OT3 complexed with nicotinamide adenine dinucleotide phosphate.

First Author  Yoshikawa S Year  2007
Journal  Acta Crystallogr D Biol Crystallogr Volume  63
Pages  357-65 PubMed ID  17327673
Issue  Pt 3

Publication Annotations Displayer

1 Bio Entities

DB identifier Name Short Name Type Description
IPR023519 Glyoxylate reductase GyaR Glyoxylate_reductase_GyaR Family The GyaR family of glyoxylate reductases catalyses the NADH-linked reduction of glyoxylate to glycolate. This family is found in hyperthermophilic archaea, where it is thought to play an important role in the glyoxylate and 3-hydroxypropionic acid cycles []. Structurally, GyaR is similar to other NADH-linked dehydrogenases []. The enzyme's thermostability appears to be due to the presence of aromatic clusters and the fact that it has more ion pairs and a relatively lower hydrophobic accessible surface area than mesophilic enzymes.

0 Cross References