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Gene : GUN5 A. thaliana

Gene ID  ? AT5G13630
Brief Description  magnesium-chelatase subunit chlH, chloroplast, putative / Mg-protoporphyrin IX chelatase, putative (CHLH)  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? GENOMES UNCOUPLED 5 (GUN5); FUNCTIONS IN: magnesium chelatase activity; INVOLVED IN: chlorophyll biosynthetic process, biosynthetic process; LOCATED IN: mitochondrion, magnesium chelatase complex, chloroplast, chloroplast inner membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: CobN/magnesium chelatase (InterPro:IPR003672), Magnesium-chelatase, subunit H (InterPro:IPR011771).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes magnesium chelatase involved in plastid-to-nucleus signal transduction.  Source: TAIR, Jun 30, 2015.
Name  ? GENOMES UNCOUPLED 5
  • synonyms:
  • CCH,
  • ABA-BINDING PROTEIN,
  • CONDITIONAL CHLORINA,
  • CHLH,
  • ABAR,
  • CCH1,
  • H SUBUNIT OF MG-CHELATASE

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10 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
Arabidopsis ABAR/CHLH specifically binds ABA (abscisic acid), and mediates ABA signalling as a positive regulator in seed germination, post-germination growth and stomatal movement, showing that ABAR/CHLH is an ABA receptor [ABAR] 17051210
ABAR/CHLH is an ABA receptor and reveal that the C-terminal half of ABAR/CHLH plays a central role in ABA signaling. 19535472
Timing of chlorophyll-AB expression protein TOC1 is induced by abscisic acid (ABA)signaling; this induction is gated by the clock and determines the timing of TOC1 binding to the ABA-related gene promoter. 19816401
ABAR spans the chloroplast envelope and that the cytosolic C terminus of ABAR interacts with a group of WRKY transcription factors that function as negative regulators of ABA signaling in seed germination and postgermination growth. 20543028
Data show that mutant subunits act as inhibitors of ChlH, and this inhibition is reversed upon addition of Gun4. 21110975
ChlH and GUN4 use distinct mechanisms to associate with chloroplast membranes. 21467578
A missense mutation of CHLH (L690 to F) is responsible for phenotype in which stomatal movements are insensitive to abscisic acid. 21562844
HSP90 proteins respond to the tetrapyrrole-mediated plastid signal to control expression of photosynthesis-associated nuclear genes 22201048
findings provide clear evidence that the Mg-chelatase-catalyzed Mg-ProtoIX production is distinct from ABA signaling, giving information to understand the mechanism by which the two cellular processes differs at the molecular level 23011401
OST1 functions downstream of ABAR in abscisic acid receptor signalling in guard cells. Consistent with this, ABAR protein is phosphorylated, but independently of the OST1 protein kinase. 26175350

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT5G13630 0.5kb upstream 0.5kb upstream 5623   true Chr5: 4387307-4392929
AT5G13630 0.5kb upstream 0.5kb upstream 500   false Chr5: 4392430-4392929
AT5G13630 0.5kb downstream 0.5kb downstream 5623   true Chr5: 4386807-4392429
AT5G13630 0.5kb downstream 0.5kb downstream 500   false Chr5: 4386807-4387306
AT5G13630 1.0kb upstream 1.0kb upstream 6123   true Chr5: 4387307-4393429
AT5G13630 1.0kb upstream 1.0kb upstream 1000   false Chr5: 4392430-4393429
AT5G13630 1.0kb downstream 1.0kb downstream 6123   true Chr5: 4386307-4392429
AT5G13630 1.0kb downstream 1.0kb downstream 1000   false Chr5: 4386307-4387306
AT5G13630 3.0kb upstream 3.0kb upstream 8123   true Chr5: 4387307-4395429
AT5G13630 3.0kb upstream 3.0kb upstream 3000   false Chr5: 4392430-4395429
AT5G13630 3.0kb downstream 3.0kb downstream 8123   true Chr5: 4384307-4392429
AT5G13630 3.0kb downstream 3.0kb downstream 3000   false Chr5: 4384307-4387306

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3 Pathways

Data Source: KEGG

Identifier Name
01100 Metabolic pathways
01110 Biosynthesis of secondary metabolites
00860 Porphyrin and chlorophyll metabolism

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10 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from UniProt GO annotations assigned by UniProt 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139