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Gene : PP2A A. thaliana

Gene ID  ? AT1G69960
Brief Description  serine/threonine protein phosphatase 2A  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? serine/threonine protein phosphatase 2A (PP2A); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: protein phosphatase 2A-2 (TAIR:AT1G10430.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? type 2A serine/threonine protein phosphatase (PP2A) mRNA,  Source: TAIR, Jun 30, 2015.
Name  ? serine/threonine protein phosphatase 2A

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9 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
PP2A and PINOID both partially colocalize with PINs and act antagonistically on the phosphorylation state of their central hydrophilic loop, hence mediating PIN apical-basal polar targeting. 17889649
Data reveal a crucial function for PP2A in dephosphorylating and activating BZR1 and completes the set of core components of the brassinosteroid-signalling cascade from cell surface receptor kinase to gene regulation in the nucleus. 21258370
PP2A exerts multilevel control on HMGR through the five-member B'' protein family during normal development and in response to a variety of stress conditions. 21478440
PP2A directly interacts with the ACS6 protein, and PP2A complexes dephosphorylate a carboxy-terminal ACS6 phosphopeptide in vitro. 21533019
A protein complex that targets protein phosphatase 2A activity to microtubules, comprises TONNEAU1 and a PP2A heterotrimeric holoenzyme with FASS as regulatory subunit, is recruited to the cytoskeleton via the TONNEAU1-recruiting motif family of proteins. 23673648
Phosphatidic acid interacts with the scaffolding A1 subunit of Protein Phosphatase 2A (PP2A) and regulates PP2A-mediated PIN1 dephosphorylation in Arabidopsis. 23686948
This work identifies PP2A as an important negative regulator of plant innate immunity that controls BAK1 activation in surface-localized immune receptor complexes. 25085430
The PP2A inhibitor phosphorylated alpha-endosulfine (ENSA)/ARPP-19 is highly conserved across plant species. ENSA/ARPP-19 is only expressed in a selection of Arabidopsis thaliana tissues. 25666948
More detailed analyses suggested an interaction network between abscissic acid-activated SnRK2-type protein kinases and several PP2A-type protein phosphatase regulatory subunits. 26175513

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT1G69960 0.5kb upstream 0.5kb upstream 2477   true Chr1: 26348721-26351197
AT1G69960 0.5kb upstream 0.5kb upstream 500   false Chr1: 26350698-26351197
AT1G69960 0.5kb downstream 0.5kb downstream 2477   true Chr1: 26348221-26350697
AT1G69960 0.5kb downstream 0.5kb downstream 500   false Chr1: 26348221-26348720
AT1G69960 1.0kb upstream 1.0kb upstream 2977   true Chr1: 26348721-26351697
AT1G69960 1.0kb upstream 1.0kb upstream 1000   false Chr1: 26350698-26351697
AT1G69960 1.0kb downstream 1.0kb downstream 2977   true Chr1: 26347721-26350697
AT1G69960 1.0kb downstream 1.0kb downstream 1000   false Chr1: 26347721-26348720
AT1G69960 3.0kb upstream 3.0kb upstream 4977   true Chr1: 26348721-26353697
AT1G69960 3.0kb upstream 3.0kb upstream 3000   false Chr1: 26350698-26353697
AT1G69960 3.0kb downstream 3.0kb downstream 4977   true Chr1: 26345721-26350697
AT1G69960 3.0kb downstream 3.0kb downstream 3000   false Chr1: 26345721-26348720

Proteins

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Function

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1 Pathways

Data Source: KEGG

Identifier Name
03015 mRNA surveillance pathway

Gene --> Ontology term

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Expression

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Array Expression

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Interactions

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11 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from TIGR GO annotations assigned by TIGR Arabidopsis annotation effort 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139