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Gene : SMG7 A. thaliana

Gene ID  ? AT5G19400
Brief Description  Telomerase activating protein Est1  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? SMG7; CONTAINS InterPro DOMAIN/s: Telomerase activating protein Est1 (InterPro:IPR019458); BEST Arabidopsis thaliana protein match is: Telomerase activating protein Est1 (TAIR:AT1G28260.2).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes SMG7, a protein that possesses an evolutionarily conserved EST1 domain and exhibits strong homology to human SMG6 (EST1A) and SMG7 (EST1C) proteins. SMG7 plays an evolutionarily conserved role in nonsense-mediated RNA decay (NMD). Required for exit from meiosis. Hypomorphic smg7 alleles render mutant plants sterile by causing an unusual cell-cycle arrest in anaphase II that is characterized by delayed chromosome decondensation and aberrant rearrangement of the meiotic spindle. Disruption of SMG7 causes embryonic lethality.  Source: TAIR, Jun 30, 2015.

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2 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
Data indicates that SMG7 counteracts cyclin-dependent kinase (CDK) activity at the end of meiosis, and reveals a novel link between SMG7 and regulation of the meiotic cell cycle. [SMG7] 18544632
Results propose a model that meiotic progression in Arabidopsis pollen mother cells is driven by a yet to be identified cyclin-CDK activity that is modulated by regulatory interactions between TDM1, SMG7, and TAM (CYCA1;2) 21119056


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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT5G19400 0.5kb upstream 0.5kb upstream 5656   true Chr5: 6539426-6545081
AT5G19400 0.5kb upstream 0.5kb upstream 500   false Chr5: 6539426-6539925
AT5G19400 0.5kb downstream 0.5kb downstream 5656   true Chr5: 6539926-6545581
AT5G19400 0.5kb downstream 0.5kb downstream 500   false Chr5: 6545082-6545581
AT5G19400 1.0kb upstream 1.0kb upstream 6156   true Chr5: 6538926-6545081
AT5G19400 1.0kb upstream 1.0kb upstream 1000   false Chr5: 6538926-6539925
AT5G19400 1.0kb downstream 1.0kb downstream 6156   true Chr5: 6539926-6546081
AT5G19400 1.0kb downstream 1.0kb downstream 1000   false Chr5: 6545082-6546081
AT5G19400 3.0kb upstream 3.0kb upstream 8156   true Chr5: 6536926-6545081
AT5G19400 3.0kb upstream 3.0kb upstream 3000   false Chr5: 6536926-6539925
AT5G19400 3.0kb downstream 3.0kb downstream 8156   true Chr5: 6539926-6548081
AT5G19400 3.0kb downstream 3.0kb downstream 3000   false Chr5: 6545082-6548081


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1 Pathways

Data Source: KEGG

Identifier Name
03015 mRNA surveillance pathway

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11 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from TAIR GO annotations assigned by TAIR 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139