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Gene : CPK6 A. thaliana

Gene ID  ? AT2G17290
Brief Description  Calcium-dependent protein kinase family protein  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? calcium dependent protein kinase 6 (CPK6); FUNCTIONS IN: in 6 functions; INVOLVED IN: regulation of anion channel activity, protein amino acid phosphorylation, N-terminal protein myristoylation, abscisic acid mediated signaling pathway, regulation of stomatal movement; LOCATED IN: cytosol, plasma membrane, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Serine/threonine-protein kinase domain (InterPro:IPR002290), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), EF-HAND 2 (InterPro:IPR018249), Calcium-dependent protein kinase (InterPro:IPR020642), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: calmodulin-domain protein kinase 5 (TAIR:AT4G35310.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes calcium dependent protein kinase 6 (CPK6), a member of the Arabidopsis CDPK gene family. CDPKs contain an intrinsic Ca2 -activation domain with four EF hand Ca2 -binding sites. CDPKs protein kinases have been proposed to function in multiple plant signal transduction pathways downstream of [Ca2 ]cyt elevations, thus transducing various physiological responses. CPK6 is expressed in both guard cells and mesophyll cells. Functions in guard cell ion channel regulation. ABA and Ca(2 ) activation of slow-type anion channels and, interestingly, ABA activation of plasma membrane Ca(2 )-permeable channels were impaired in independent alleles of single and double cpk3cpk6 mutant guard cells. Furthermore, ABA- and Ca(2 )-induced stomatal closing were partially impaired in these cpk3cpk6 mutant alleles. The protein kinase CPK6 is shown in biochemical assays to be directly activated by elevations in calcium concentrations in the physiological range (Laanements et al., 2013 PlantPhys.; PMID: 23766366). These data correlate with the in vivo function of CPK6 in Ca2 and ABA activation of S-type anion channels (Mori et al., 2006 PLoS Biol.; PMID: 17032064) and the ability of CPK6 to mediate ABA activation of SLAC1 (Brandt et al., 2012 PNAS; PMID: 22689970).  Source: TAIR, Jun 30, 2015.
Name  ? calcium dependent protein kinase 6
  • synonyms:
  • ARABIDOPSIS THALIANA CALMODULIN-DOMAIN PROTEIN KINASE 3,
  • ATCDPK3,
  • ARABIDOPSIS THALIANA CALCIUM-DEPENDENT PROTEIN KINASE 6,
  • ATCPK6

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5 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
CPK6 functions in guard cell ion channel regulation and provide genetic evidence for calcium sensors that transduce stomatal ABA signaling. 17032064
AtCPK6 is functionally redundant and a positive regulator involved in the tolerance to salt/drought stress in Arabidopsis. 20217124
These results provide genetic evidence that CPK6 has a different role from CPK3 and functions as a positive regulator of methyl jasmonate signaling in Arabidopsis guard cells. 20978156
CPK6 positively functions in induction by yeast elicitor (YEL) of stomatal closure and inhibition by YEL of light-induced stomatal opening in Arabidopsis. 23922271
(CPK6 and CPK33) are expressed in shoot apical meristem and directly interact with FD, suggesting they have redundant functions 25661797

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT2G17290 0.5kb upstream 0.5kb upstream 3833   true Chr2: 7515830-7519662
AT2G17290 0.5kb upstream 0.5kb upstream 500   false Chr2: 7515830-7516329
AT2G17290 0.5kb downstream 0.5kb downstream 3833   true Chr2: 7516330-7520162
AT2G17290 0.5kb downstream 0.5kb downstream 500   false Chr2: 7519663-7520162
AT2G17290 1.0kb upstream 1.0kb upstream 4333   true Chr2: 7515330-7519662
AT2G17290 1.0kb upstream 1.0kb upstream 1000   false Chr2: 7515330-7516329
AT2G17290 1.0kb downstream 1.0kb downstream 4333   true Chr2: 7516330-7520662
AT2G17290 1.0kb downstream 1.0kb downstream 1000   false Chr2: 7519663-7520662
AT2G17290 3.0kb upstream 3.0kb upstream 6333   true Chr2: 7513330-7519662
AT2G17290 3.0kb upstream 3.0kb upstream 3000   false Chr2: 7513330-7516329
AT2G17290 3.0kb downstream 3.0kb downstream 6333   true Chr2: 7516330-7522662
AT2G17290 3.0kb downstream 3.0kb downstream 3000   false Chr2: 7519663-7522662

Proteins

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1 Pathways

Data Source: KEGG

Identifier Name
04626 Plant-pathogen interaction

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11 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from GOC GO annotations assigned by the GO Consortium 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139