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Gene : BAK1 A. thaliana

Gene ID  ? AT4G33430
Brief Description  BRI1-associated receptor kinase  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? BRI1-associated receptor kinase (BAK1); FUNCTIONS IN: protein binding, protein serine/threonine kinase activity, protein heterodimerization activity, kinase activity; INVOLVED IN: in 6 processes; LOCATED IN: endosome, plasma membrane, protein complex; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: somatic embryogenesis receptor-like kinase 4 (TAIR:AT2G13790.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Leu-rich receptor Serine/threonine protein kinase. Component of BR signaling that interacts with BRI1 in vitro and in vivo to form a heterodimer. Brassinolide-dependent association of BRI1 and BAK1 in vivo. Phosphorylation of both BRI1 and BAK1 on Thr residues was BR dependent. Although BAK1 and BRI1 alone localize in the plasma membrane, when BAK1 and BRI1 are coexpressed, the heterodimer BAK1/BRI1 they form is localized in the endosome.  Source: TAIR, Jun 30, 2015.
Name  ? BRI1-associated receptor kinase
  • synonyms:
  • RKS10,
  • ATSERK3,
  • ELG,
  • SERK3,
  • ATBAK1

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44 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
We propose that the AtSERK3 protein is involved in changing the equilibrium between plasma membrane-located BRI1 homodimers and endocytosed BRI1-AtSERK3 heterodimers. 15548744
In vivo association of BRI1 and BAK1 was affected by endogenous and exogenous BR levels and that phosphorylation of both BRI1 and BAK1 on Thr residues was BR dependent. 15894717
A previously identified photomorphogenesis mutant, elg, enhances high-light phototropism and represents a unique allele of BAK1/SERK3, a receptor kinase implicated in brassinosteroid perception. 16126860
The effects of ectopic expression of BAK1 in transgenic rice on plant growth and plant growth regulators is reported. 17027118
study demonstrates that BAK1 and BKK1 (AtSERK4) have dual physiological roles: positively regulating a brassinosteroid (BR)-dependent plant growth pathway, and negatively regulating a BR-independent cell-death pathway 17600708
FLS2 and BAK1 form a complex in vivo, in a specific ligand-dependent manner, within the first minutes of stimulation with flagellin 17625569
SERK3/BAK1 appears to integrate diverse perception events into downstream pathogen-associated molecular pattern responses, leading to immunity against a range of invading microbes. 17626179
The paper shows that AvrPto and AvrPtoB bind the Arabidopsis receptor-like kinase BAK1, a shared signaling partner of both the flagellin receptor FLS2 and the brassinosteroid receptor BRI1. 18621007
controls plant innate immunity, is the coreceptor of the flagellin receptor FLS2, and, together with SERK4, can mediate cell death control, all three in a brassinolide-independent fashion 18667726
Brassinosteroids-dependent activation of BRI1 precedes association with BAK1 in planta, and that BRI1 positively regulates BAK1 phosphorylation levels in vivo. 18694562
AtGSTF10 is involved in stress tolerance and the BAK1-mediated spontaneous cell death signaling pathway in Arabidopsis. 19118534
cytoplasmic domains of BRI1 and BAK1 also autophosphorylate on tyrosine residues and thus are dual-specificity kinases. 19124768
several leucine-rich repeat receptor kinases form tight complexes with BAK1 almost instantaneously after ligand binding and the subsequent phosphorylation events are key initial steps in signal transduction 20103591
Results establish a site-specific role for Tyr phosphorylation of BAK1 in BR signaling and regulation of plant defense mechanisms, which may have implications for enhancing agricultural productivity. 21350342
BAK1-dependent signaling pathways are differentially regulated by a novel allele of BAK1, bak1-5. 21593986
BON1 and BIR1 can be phosphorylated by BAK1 in vitro 21623975
BAK1 participates in the maintenance of the microbe-associated molecular patterns (MAMP)-specific response. 21668535
study has revealed a unique regulatory circuit of direct ubiquitination and turnover of FLS2 by BAK1-mediated phosphorylation and recruitment of specific E3 ligases (PUB12,PUB13) for attenuation of immune signaling 21680842
Data reveal that PAMP-triggered immunity (PTI) relies on ligand-induced recruitment of SERK3/4 and provides insight into the early PTI signaling events underlying this important layer of plant innate immunity. 21693696
crystal of BAK1 belonged to space group C2, with unit-cell parameters a = 70.3, b = 75.6, c = 71.9 A, beta = 93.1 degrees 22442239
serk1 bak1 bkk1 triple mutant exhibited drastically reduced expression of a number of genes critical to polar auxin transport, cell cycle, endodermis development and root meristem differentiatio 22525267
Initial phosphorylation of the BAK1 activation loop locks BAK1 kinase in the active conformation. BAK1 phosphorylates and activates RLK, which phosphorylates downstream substrates for signal transduction and the development of innate immune response. 22547027
bak1/elg-D promotes Arabidopsis growth by stimulating BR signaling at the expense of its readiness to respond to biotic stress factors 22961663
Colocalization of BRI1 and SERK3 in the plasma membrane is influenced by the brassinosteroid signaling status. 23796795
BAK1-dependent PTI contributes to antiviral resistance in plants. 23902263
Studies identified an LRR-RLK protein kinase (AT3g23750), and named it BAK1-Associating Receptor-Like Kinase 1 (BARK1) specifically binding to BAK1. 23921992
Genetic analysis of brl1 brl3 bak1-3 triple mutants revealed that BAK1, BRL1, and BRL3 signaling modulate root growth and development by contributing to the cellular activities of provascular and quiescent center cells. 24064770
Data indicate that the model included the contribution of the coreceptors SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 and SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE3 in BRASSINOSTEROID INSENSITIVE1 activities. 24072582
RLP30, BAK1, and SOBIR1/EVR contribute to resistance against necrotrophic fungi. 24104566
these data reveal the molecular mechanisms underlying FLS2-BAK1 complex recognition of flg22 and provide insight into the immune receptor complex activation. 24114786


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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT4G33430 0.5kb upstream 0.5kb upstream 5022   true Chr4: 16086311-16091332
AT4G33430 0.5kb upstream 0.5kb upstream 500   false Chr4: 16090833-16091332
AT4G33430 0.5kb downstream 0.5kb downstream 5022   true Chr4: 16085811-16090832
AT4G33430 0.5kb downstream 0.5kb downstream 500   false Chr4: 16085811-16086310
AT4G33430 1.0kb upstream 1.0kb upstream 5522   true Chr4: 16086311-16091832
AT4G33430 1.0kb upstream 1.0kb upstream 1000   false Chr4: 16090833-16091832
AT4G33430 1.0kb downstream 1.0kb downstream 5522   true Chr4: 16085311-16090832
AT4G33430 1.0kb downstream 1.0kb downstream 1000   false Chr4: 16085311-16086310
AT4G33430 3.0kb upstream 3.0kb upstream 7522   true Chr4: 16086311-16093832
AT4G33430 3.0kb upstream 3.0kb upstream 3000   false Chr4: 16090833-16093832
AT4G33430 3.0kb downstream 3.0kb downstream 7522   true Chr4: 16083311-16090832
AT4G33430 3.0kb downstream 3.0kb downstream 3000   false Chr4: 16083311-16086310


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2 Pathways

Data Source: KEGG

Identifier Name
04626 Plant-pathogen interaction
04075 Plant hormone signal transduction

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12 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from UniProt GO annotations assigned by UniProt 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139