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Gene : HYL1 A. thaliana

Gene ID  ? AT1G09700
Brief Description  dsRNA-binding domain-like superfamily protein  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? HYPONASTIC LEAVES 1 (HYL1); CONTAINS InterPro DOMAIN/s: Double-stranded RNA-binding (InterPro:IPR001159), Double-stranded RNA-binding-like (InterPro:IPR014720); BEST Arabidopsis thaliana protein match is: dsRNA-binding protein 2 (TAIR:AT2G28380.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes a nuclear dsRNA binding protein. Involved in mRNA cleavage. The mutant is characterized by shorter stature, delayed flowering, leaf hyponasty, reduced fertility, decreased rate of root growth, and an altered root gravitropic response. It also exhibits less sensitivity to auxin and cytokinin.  Source: TAIR, Jun 30, 2015.
Name  ? HYPONASTIC LEAVES 1
  • synonyms:
  • DSRNA-BINDING PROTEIN 1,
  • AtDRB1,
  • DRB1

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19 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
HYL1 has a function in assisting efficient and precise cleavage of pri-miRNA through interaction with DCL1 16428603
The N-terminal double-stranded RNA binding domains fulfill the function of the whole HYL1 and thus play an essential role in miRNA processing and miRNA-directed silencing of targeted genes. 17337628
the distinct HYL1- and DCL1-containing nuclear bodies may be miRNA precursor processing sites or assembly and storage sites for the miRNA precursor processing machinery 17369351
we found that DCL1, HYL1 & SE formed bodies which localized in the nuclei; we were also able to locate the miRNA primary transcript on these bodies; it appears very likely that the observed DCL1-HYL1-SE nuclear body is involved in miRNA production 17675322
SINE RNA interacts with HYL1 that associates with the Dicer homologue DCL1 to produce microRNAs. 18551175
Genetic screening identified a novel semidominant mutation in DCL1 (dcl1-13), this mutation confers significant restoration from the developmental abnormality and a reduction in the level of miRNA in the loss-of-function mutant of HYL1. 19155326
In the hyl1 mutant intron-containing pri-miRNAs accumulate alongside spliced pri-miRNAs suggesting the recruitment of HYL1 into the miRNA precursor maturation pathway before their splicing occurs. 19304749
suggests that small RNA processing in the DCL1/DRB1-directed miRNA and DCL4/DRB4-directed sRNA biogenesis pathways operates via different mechanisms. 19861421
HYL1 monitors the roles of miR165/166, miR319a, and miR160 in leaf flattening through the relative activities of adaxial and abaxial identity genes. 21610018
HYL1 controls the miR156-mediated juvenile phase of vegetative growth. 22268150
AGO1, HYL1, and HEN1 function in proximal-distal and vascular patterning of leaves. 22623415
In the miRNA processing complex, Serrate functions as a scaffold to mediate CPL1 interaction with HYL1, which needs to be dephosphorylated for optimal activity. In 23141542
The C-terminal dsRBDs of DCL1 and N-terminal dsRBDs of HYL1 have parallel roles. 23886622
The role of HYL1 is in establishment of stamen architecture provides insight into the molecular mechanism of male fertility. 23918970
The results suggest that HYL1 ensures the correct selection of pri-miRNA cleavage sites through homodimerization and thus contributes to gene silencing and plant development. 25294831
Data establishes that RNA binding by HYL1 dsRBD1 is essential for its function. 25409478
MicroRNA biogenesis factor DRB1 is a phosphorylation target of mitogen activated protein kinase MPK3 in both rice and Arabidopsis 25417716
cytoplasmic partitioning of COP1 under light is essential to protect HYL1 against protease X. 25532508
Data suggest a mechanism of plant miRNA maturation which involves binding of the HEN1 methyltransferase to the DICER-LIKE 1 ribonuclease DCL1*RNA-binding protein HYL1*miRNA complex. 25680966

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT1G09700 0.5kb upstream 0.5kb upstream 3205   true Chr1: 3137649-3140853
AT1G09700 0.5kb upstream 0.5kb upstream 500   false Chr1: 3140354-3140853
AT1G09700 0.5kb downstream 0.5kb downstream 3205   true Chr1: 3137149-3140353
AT1G09700 0.5kb downstream 0.5kb downstream 500   false Chr1: 3137149-3137648
AT1G09700 1.0kb upstream 1.0kb upstream 3705   true Chr1: 3137649-3141353
AT1G09700 1.0kb upstream 1.0kb upstream 1000   false Chr1: 3140354-3141353
AT1G09700 1.0kb downstream 1.0kb downstream 3705   true Chr1: 3136649-3140353
AT1G09700 1.0kb downstream 1.0kb downstream 1000   false Chr1: 3136649-3137648
AT1G09700 3.0kb upstream 3.0kb upstream 5705   true Chr1: 3137649-3143353
AT1G09700 3.0kb upstream 3.0kb upstream 3000   false Chr1: 3140354-3143353
AT1G09700 3.0kb downstream 3.0kb downstream 5705   true Chr1: 3134649-3140353
AT1G09700 3.0kb downstream 3.0kb downstream 3000   false Chr1: 3134649-3137648

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11 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from GOC GO annotations assigned by the GO Consortium 8/01/2016
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139