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Gene : C4H A. thaliana

Gene ID  ? AT2G30490
Brief Description  cinnamate-4-hydroxylase  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? cinnamate-4-hydroxylase (C4H); FUNCTIONS IN: trans-cinnamate 4-monooxygenase activity; INVOLVED IN: in 9 processes; LOCATED IN: endoplasmic reticulum, plasma membrane, membrane, plant-type cell wall; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 98, subfamily A, polypeptide 3 (TAIR:AT2G40890.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes a cinnamate-4-hydroxylase. Mutations in this gene impact phenylpropanoid metabolism, growth and development.  Source: TAIR, Jun 30, 2015.
Name  ? cinnamate-4-hydroxylase
  • synonyms:
  • CYP73A5,
  • CINNAMATE 4-HYDROXYLASE,
  • REDUCED EPRDERMAL FLUORESCENCE 3,
  • REF3,
  • ATC4H

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2 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
C4H function is critical to normal development of Arabidopsis. 19682296
CYP73A5 and CYP98A3, the two Arabidopsis cytochrome P450s (P450s) catalyzing para- and meta-hydroxylations of the phenolic ring of monolignols were found to colocalize in the endoplasmic reticulum (ER) and to form homo- and heteromers. 23175744

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT2G30490 0.5kb upstream 0.5kb upstream 2888   true Chr2: 12993625-12996512
AT2G30490 0.5kb upstream 0.5kb upstream 500   false Chr2: 12996013-12996512
AT2G30490 0.5kb downstream 0.5kb downstream 2888   true Chr2: 12993125-12996012
AT2G30490 0.5kb downstream 0.5kb downstream 500   false Chr2: 12993125-12993624
AT2G30490 1.0kb upstream 1.0kb upstream 3388   true Chr2: 12993625-12997012
AT2G30490 1.0kb upstream 1.0kb upstream 1000   false Chr2: 12996013-12997012
AT2G30490 1.0kb downstream 1.0kb downstream 3388   true Chr2: 12992625-12996012
AT2G30490 1.0kb downstream 1.0kb downstream 1000   false Chr2: 12992625-12993624
AT2G30490 3.0kb upstream 3.0kb upstream 5388   true Chr2: 12993625-12999012
AT2G30490 3.0kb upstream 3.0kb upstream 3000   false Chr2: 12996013-12999012
AT2G30490 3.0kb downstream 3.0kb downstream 5388   true Chr2: 12990625-12996012
AT2G30490 3.0kb downstream 3.0kb downstream 3000   false Chr2: 12990625-12993624

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7 Pathways

Data Source: KEGG

Identifier Name
01100 Metabolic pathways
01110 Biosynthesis of secondary metabolites
00940 Phenylpropanoid biosynthesis
00360 Phenylalanine metabolism
00130 Ubiquinone and other terpenoid-quinone biosynthesis
00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
00941 Flavonoid biosynthesis

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Expression

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12 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from InterPro    
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
IntAct interactions data set Curated binary and complex protein-protein interactions for Arabidopsis thaliana 8/02/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139