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Gene : BR6OX2 A. thaliana

Gene ID  ? AT3G30180
Brief Description  brassinosteroid-6-oxidase 2  Source: Araport11 (06/2016).
Is Obsolete?  false
Computational Description  ? brassinosteroid-6-oxidase 2 (BR6OX2); FUNCTIONS IN: monooxygenase activity, oxygen binding; INVOLVED IN: response to light stimulus, circadian rhythm, brassinosteroid biosynthetic process; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: brassinosteroid-6-oxidase 1 (TAIR:AT5G38970.1).  Source: TAIR, Jun 30, 2015.
Curator Summary  ? Encodes a cytochrome p450 enzyme that catalyzes the last reaction in the production of brassinolide. It is capable of converting 6-deoxocastasterone into castasterone, a C-6 oxidation, as well as the further conversion of castasterone into brassinolide by a Baeyer-Villinger oxidation reaction at C-6, resulting in the formation of an unusual seven-membered lactone ring. The enzyme possesses high affinity for both C28- and C27-Brassinosteroids. The expression of the gene using a CYP85A2 promoter:LUC fusion construct was shown to be under circadian and light control.  Source: TAIR, Jun 30, 2015.
Name  ? brassinosteroid-6-oxidase 2
  • synonyms:
  • CYP85A2

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4 GeneRIFs (Gene References Into Functions)

Data Source: NCBI

Annotation PubMed Id
investigated the temporal and spatial expression patterns of CYP85A1 and CYP85A2; both promoters of CYP85A1 and CYP85A2 showed maximum activity during the first week following germination, particularly in the vascular tissues 15821873
CYP85A2 is a bifunctional enzyme that possesses BR C-6 oxidase (C-6 oxidation of brassinosteroids) and brassinolide (BL) synthase activity. It is thus a cytochrome P450 that mediates Baeyer-Villiger oxidation in plants. [CYP85A2] 16024588
CYP85A2 catalyzes the lactonization reactions of not only castasterone but also teasterone and typhasterol 18685225
The seu cyp85A2 double mutants displayed enhanced disruptions of gynoecial and ovule development. 20836864

Genomics

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12 Flanking Regions

Flank size: from most upstream transcription start site, or most downstream transcription stop site

Region Name Flank Size Direction Length Gene Included? Chromosome Location
AT3G30180 0.5kb upstream 0.5kb upstream 3658   true Chr3: 11810226-11813883
AT3G30180 0.5kb upstream 0.5kb upstream 500   false Chr3: 11810226-11810725
AT3G30180 0.5kb downstream 0.5kb downstream 3658   true Chr3: 11810726-11814383
AT3G30180 0.5kb downstream 0.5kb downstream 500   false Chr3: 11813884-11814383
AT3G30180 1.0kb upstream 1.0kb upstream 4158   true Chr3: 11809726-11813883
AT3G30180 1.0kb upstream 1.0kb upstream 1000   false Chr3: 11809726-11810725
AT3G30180 1.0kb downstream 1.0kb downstream 4158   true Chr3: 11810726-11814883
AT3G30180 1.0kb downstream 1.0kb downstream 1000   false Chr3: 11813884-11814883
AT3G30180 3.0kb upstream 3.0kb upstream 6158   true Chr3: 11807726-11813883
AT3G30180 3.0kb upstream 3.0kb upstream 3000   false Chr3: 11807726-11810725
AT3G30180 3.0kb downstream 3.0kb downstream 6158   true Chr3: 11810726-11816883
AT3G30180 3.0kb downstream 3.0kb downstream 3000   false Chr3: 11813884-11816883

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Function

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3 Pathways

Data Source: KEGG

Identifier Name
01100 Metabolic pathways
01110 Biosynthesis of secondary metabolites
00905 Brassinosteroid biosynthesis

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11 Data Sets

Name Description Version
BAR Annotations Lookup Mapping(s) between AGI locus and Affy Probeset identifier 10/08/2013
Genome Annotation Araport11 protein-coding, non-coding and transposable element genes Araport11 (06/2016)
RNA-seq expression Measure of gene expression levels (Transcripts per Million, TPM) quantified by Salmon Araport11 (06/2016)
PubMed to gene mapping Curated associations between publications and NCBI Gene records 8/12/2016
GO Annotation from InterPro    
PO Annotation from TAIR Literature-based annotations of genes to Plant Ontology (PO) terms 06/30/2015
Swiss-Prot data set High-quality, manually annotated, non-redundant protein sequence database 2016_07
Panther data set PANTHER paralogs from Arabidopsis 11.0
KEGG pathways data set Wiring diagrams of molecular interactions, reactions, and relations 79.0
GeneRIF Concise phrase describing gene function and publication associated with NCBI Gene records 8/12/2016
BioGRID interaction data set Curated set of genetic and physical interactions for Arabidopsis thaliana 3.4.139