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Publication : MKK5 regulates high light-induced gene expression of Cu/Zn superoxide dismutase 1 and 2 in Arabidopsis.

First Author  Xing Y Year  2013
Journal  Plant Cell Physiol Volume  54
Pages  1217-27 PubMed ID  23677921
Issue  7

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5 Bio Entities

Class Gene ID Symbol Brief Description Is Obsolete? Length Molecular Weight Name Short Name Type Description
Gene AT1G08830 CSD1 copper/zinc superoxide dismutase 1 false            
Gene AT2G28190 CSD2 copper/zinc superoxide dismutase 2 false            
Gene AT3G21220 MKK5 MAP kinase kinase 5 false            
Protein M2K5_ARATH       348   38329        
ProteinDomain IPR031074           Superoxide dismutase [Cu-Zn], chloroplastic CSD2_chloroplastic Family Chloroplastic copper/zinc superoxide dismutase CSD2 can detoxify superoxide radicals, its expression is regulated by miR398 [, ]. MicroRNAs (miRNAs) recognise target mRNAs for degradation or translational repression and play important roles in plant growth, development, and stress responses. Down-regulation of miR398 in response to oxidative stress permits up-regulation of CSD2, and thereby helps plants to cope with oxidative stress []. On the other hand, down-regulation of CSD2 by heat-induced miR398 is required for heat tolerance [, ]. CSD2 is also involved in the oxidative adaptation to high light stress. MKK5, a mitogen-activated protein kinase kinase, mediates the high light-induced expression of CSD2 [].Superoxide dismutases (SODs) are ubiquitous metalloproteins that prevent damageby oxygen-mediated free radicals by catalysing the dismutation of superoxideinto molecular oxygen and hydrogen peroxide []. Superoxide is a normal by-product of aerobic respiration and is produced by a number of reactions, including oxidative phosphorylation and photosynthesis. The dismutaseenzymes have a very high catalytic efficiency due to the attraction ofsuperoxide to the ions bound at the active site [, ].There are three forms of superoxide dismutase, depending on the metal cofactor: Cu/Zn (which binds both copper and zinc), Fe and Mn types. The Fe and Mnforms are similar in their primary, secondary and tertiary structures, but are distinct from the Cu/Zn form []. Prokaryotes and protists contain Mn,Fe or both types, while most eukaryotic organisms utilise the Cu/Zn type.

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